| http://purl.uniprot.org/citations/24836562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24836562 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucagon-like peptide-1 (GLP-1), an insulinotropic gut peptide released after eating, is essential for normal glucose tolerance (GT). To determine whether this effect is mediated directly by GLP-1 receptors (GLP1R) on islet β cells, we developed mice with β cell-specific knockdown of Glp1r. β cell Glp1r knockdown mice had impaired GT after intraperitoneal (i.p.) glucose and did not secrete insulin in response to i.p. or intravenous GLP-1. However, they had normal GT after oral glucose, a response that was impaired by a GLP1R antagonist. β cell Glp1r knockdown mice had blunted responses to a GLP1R agonist but intact glucose lowering with a dipeptidylpeptidase 4 (DPP-4) inhibitor. Thus, in mice, β cell Glp1rs are required to respond to hyperglycemia and exogenous GLP-1, but other factors compensate for reduced GLP-1 action during meals. These results support a role for extraislet GLP1R in oral glucose tolerance and paracrine regulation of β cells by islet GLP-1."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2014.04.005"xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "An Z."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Wagner C."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Philipson L.H."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Smith E.P."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Stoffers D.A."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Seeley R.J."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Sandoval D."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Perez-Tilve D."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Cohen E.B."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "D'Alessio D.A."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Tamarina N."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Lewis A.G."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/author | "Mahbod P."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/pages | "1050-1057"xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/title | "The role of beta cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs."xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/24836562 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24836562 |
| http://purl.uniprot.org/citations/24836562 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24836562 |
| http://purl.uniprot.org/uniprot/#_B7ZP48-mappedCitation-24836562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24836562 |