| http://purl.uniprot.org/citations/24836577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24836577 | http://www.w3.org/2000/01/rdf-schema#comment | "Cardiomyocyte T tubules are important for regulating ion flux. Bridging integrator 1 (BIN1) is a T-tubule protein associated with calcium channel trafficking that is downregulated in failing hearts. Here we find that cardiac T tubules normally contain dense protective inner membrane folds that are formed by a cardiac isoform of BIN1. In mice with cardiac Bin1 deletion, T-tubule folding is decreased, which does not change overall cardiomyocyte morphology but leads to free diffusion of local extracellular calcium and potassium ions, prolonging action-potential duration and increasing susceptibility to ventricular arrhythmias. We also found that T-tubule inner folds are rescued by expression of the BIN1 isoform BIN1+13+17, which promotes N-WASP-dependent actin polymerization to stabilize the T-tubule membrane at cardiac Z discs. BIN1+13+17 recruits actin to fold the T-tubule membrane, creating a 'fuzzy space' that protectively restricts ion flux. When the amount of the BIN1+13+17 isoform is decreased, as occurs in acquired cardiomyopathy, T-tubule morphology is altered, and arrhythmia can result."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.3543"xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Hong T."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Sun B."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Jan L.Y."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Zhang S.S."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Bhargava A."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Marban E."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Grabe M."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Shaw R.M."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Cho H.C."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Gorelik J."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Kalashnikova M."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/author | "Olgin J."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/pages | "624-632"xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/title | "Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia."xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/24836577 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24836577 |
| http://purl.uniprot.org/citations/24836577 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24836577 |
| http://purl.uniprot.org/uniprot/O08539#attribution-7A3FFB5A3FD606648A18ADAB9C89C62B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24836577 |