| http://purl.uniprot.org/citations/24837021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24837021 | http://www.w3.org/2000/01/rdf-schema#comment | "Ku-dependent C-NHEJ (classic non-homologous end joining) is the primary DNA EJing (end joining) repair pathway in mammals. Recently, an additional EJing repair pathway (A-NHEJ; alternative-NHEJ) has been described. Currently, the mechanism of A-NHEJ is obscure although a dependency on LIGIII (DNA ligase III) is often implicated. To test the requirement for LIGIII in A-NHEJ we constructed a LIGIII conditionally-null human cell line using gene targeting. Nuclear EJing activity appeared unaffected by a deficiency in LIGIII as, surprisingly, so were random gene targeting integration events. In contrast, LIGIII was required for mitochondrial function and this defined the gene's essential activity. Human Ku:LIGIII and Ku:LIGIV (DNA ligase IV) double knockout cell lines, however, demonstrated that LIGIII is required for the enhanced A-NHEJ activity that is observed in Ku-deficient cells. Most unexpectedly, however, the majority of EJing events remained LIGIV-dependent. In conclusion, although human LIGIII has an essential function in mitochondrial maintenance, it is dispensable for most types of nuclear DSB repair, except for the A-NHEJ events that are normally suppressed by Ku. Moreover, we describe that a robust Ku-independent, LIGIV-dependent repair pathway exists in human somatic cells."xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.dnarep.2014.04.015"xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/author | "Jackson P.J."xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/author | "Harvey A."xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/author | "Nguyen T."xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/author | "Oh S."xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/author | "Hendrickson E.A."xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/author | "Zimbric J."xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/name | "DNA Repair (Amst)"xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/pages | "97-110"xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/title | "DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells."xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/24837021 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24837021 |
| http://purl.uniprot.org/citations/24837021 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24837021 |
| http://purl.uniprot.org/uniprot/P49916#attribution-093A4C01BBE4A79C645DC78FB6C9BE90 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24837021 |
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