| http://purl.uniprot.org/citations/24838012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24838012 | http://www.w3.org/2000/01/rdf-schema#comment | "Ten eleven translocation (Tet) enzymes oxidize the epigenetically important DNA base 5-methylcytosine (mC) stepwise to 5-hydroxymethylcytosine (hmC), 5-formylcytosine and 5-carboxycytosine. It is currently unknown whether Tet-induced oxidation is limited to cytosine-derived nucleobases or whether other nucleobases are oxidized as well. We synthesized isotopologs of all major oxidized pyrimidine and purine bases and performed quantitative MS to show that Tet-induced oxidation is not limited to mC but that thymine is also a substrate that gives 5-hydroxymethyluracil (hmU) in mouse embryonic stem cells (mESCs). Using MS-based isotope tracing, we show that deamination of hmC does not contribute to the steady-state levels of hmU in mESCs. Protein pull-down experiments in combination with peptide tracing identifies hmU as a base that influences binding of chromatin remodeling proteins and transcription factors, suggesting that hmU has a specific function in stem cells besides triggering DNA repair."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.org/dc/terms/identifier | "doi:10.1038/nchembio.1532"xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Muller M."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Wagner M."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Vermeulen M."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Truss M."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Schuermann D."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Schar P."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Muller U."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Pfaffeneder T."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Spruijt C.G."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Leonhardt H."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Carell T."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Spada F."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Michalakis S."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Schiesser S."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Steigenberger B."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Eisen D."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Steinbacher J."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Hackner B."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Brandmayr C."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Kashiwazaki G."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Kosmatchev O."xsd:string |
| http://purl.uniprot.org/citations/24838012 | http://purl.uniprot.org/core/author | "Kotljarova O."xsd:string |