| http://purl.uniprot.org/citations/24840544 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24840544 | http://www.w3.org/2000/01/rdf-schema#comment | "The functional significance of fibrin deposits typically seen in inflammatory lesions, carcinomas and in healing wounds is not fully understood. In the present study, we demonstrate that fibrinogen/fibrin specifically bound to native Col I (collagen type I) and used the Col I fibre network as a base to provide a functional interface matrix that connects cells to the Col I fibres through αVβ3 integrins. This allowed murine myoblast C2C12 cells to contract the collagenous composite gel via αVβ3 integrin. We show that fibrinogen specifically bound to immobilized native Col I at the site known to bind matrix metalloproteinase-1, discoidin domain receptor-2 and fibronectin, and that binding had no effect on Col I fibrillation. A specific competitive inhibitor blocking the Col-I-binding site for fibrinogen abolished the organization of fibrin into discernable fibrils, as well as the C2C12-mediated contraction of Col I gels. Our data show that fibrin can function as a linkage protein between Col I fibres and cells, and suggest that fibrin at inflammatory sites indirectly connects αVβ3 integrins to Col I fibres and thereby promotes cell-mediated contraction of collagenous tissue structures."xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20140201"xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://purl.uniprot.org/core/author | "Rask L."xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://purl.uniprot.org/core/author | "Gustafsson R."xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://purl.uniprot.org/core/author | "Guss B."xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://purl.uniprot.org/core/author | "Rubin K."xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://purl.uniprot.org/core/author | "Reyhani V."xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://purl.uniprot.org/core/author | "Seddigh P."xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24840544 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://purl.uniprot.org/core/pages | "113-123"xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://purl.uniprot.org/core/title | "Fibrin binds to collagen and provides a bridge for alphaVbeta3 integrin-dependent contraction of collagen gels."xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://purl.uniprot.org/core/volume | "462"xsd:string |
| http://purl.uniprot.org/citations/24840544 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24840544 |
| http://purl.uniprot.org/citations/24840544 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24840544 |
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