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| http://purl.uniprot.org/citations/24844324 | http://www.w3.org/2000/01/rdf-schema#comment | "Degradation of p53 is a cornerstone in the control of its functions as a tumor suppressor. This process is attributed to ubiquitin-dependent modification of p53. In addition to polyubiquitination, we found that p53 is targeted for degradation through ISGylation. Isg15, a ubiquitin-like protein, covalently modifies p53 at 2 sites in the N and C terminus, and ISGylated p53 can be degraded by the 20S proteasome. ISGylation primarily targets a misfolded, dominant-negative p53, and Isg15 deletion in normal cells results in suppression of p53 activity and functions. We propose that Isg15-dependent degradation of p53 represents an alternative mechanism of controlling p53 protein levels, and, thus, it is an attractive pathway for drug discovery."xsd:string |
| http://purl.uniprot.org/citations/24844324 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.29209"xsd:string |
| http://purl.uniprot.org/citations/24844324 | http://purl.uniprot.org/core/author | "Lane D.P."xsd:string |
| http://purl.uniprot.org/citations/24844324 | http://purl.uniprot.org/core/author | "Wee S."xsd:string |
| http://purl.uniprot.org/citations/24844324 | http://purl.uniprot.org/core/author | "Huang Y.F."xsd:string |
| http://purl.uniprot.org/citations/24844324 | http://purl.uniprot.org/core/author | "Bulavin D.V."xsd:string |
| http://purl.uniprot.org/citations/24844324 | http://purl.uniprot.org/core/author | "Gunaratne J."xsd:string |
| http://purl.uniprot.org/citations/24844324 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24844324 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/24844324 | http://purl.uniprot.org/core/pages | "2200-2210"xsd:string |
| http://purl.uniprot.org/citations/24844324 | http://purl.uniprot.org/core/title | "Isg15 controls p53 stability and functions."xsd:string |
| http://purl.uniprot.org/citations/24844324 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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