| http://purl.uniprot.org/citations/24845831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24845831 | http://www.w3.org/2000/01/rdf-schema#comment | "The ketone body β-hydroxybutyrate (BHB) is an endogenous factor protecting against stroke and neurodegenerative diseases, but its mode of action is unclear. Here we show in a stroke model that the hydroxy-carboxylic acid receptor 2 (HCA2, GPR109A) is required for the neuroprotective effect of BHB and a ketogenic diet, as this effect is lost in Hca2(-/-) mice. We further demonstrate that nicotinic acid, a clinically used HCA2 agonist, reduces infarct size via a HCA2-mediated mechanism, and that noninflammatory Ly-6C(Lo) monocytes and/or macrophages infiltrating the ischemic brain also express HCA2. Using cell ablation and chimeric mice, we demonstrate that HCA2 on monocytes and/or macrophages is required for the protective effect of nicotinic acid. The activation of HCA2 induces a neuroprotective phenotype of monocytes and/or macrophages that depends on PGD2 production by COX1 and the haematopoietic PGD2 synthase. Our data suggest that HCA2 activation by dietary or pharmacological means instructs Ly-6C(Lo) monocytes and/or macrophages to deliver a neuroprotective signal to the brain."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms4944"xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Muhammad S."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Khan M.A."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Rahman M."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Offermanns S."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Muller-Fielitz H."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Okun J.G."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Schwaninger M."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Vollbrandt T."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Nadrowitz R."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Ridder D.A."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Pokorna B."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/author | "Stolting I."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/pages | "3944"xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/title | "The beta-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages."xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/24845831 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24845831 |
| http://purl.uniprot.org/citations/24845831 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24845831 |
| http://purl.uniprot.org/uniprot/#_Q0VBA6-mappedCitation-24845831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24845831 |
| http://purl.uniprot.org/uniprot/#_P22437-mappedCitation-24845831 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24845831 |