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http://purl.uniprot.org/citations/24846126http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24846126http://www.w3.org/2000/01/rdf-schema#comment"

Background

Serum cardiac troponin T (cTnT) is a valuable marker of ischemic heart disease (IHD) and left ventricular hypertrophy, as well as a mortality predictor in hemodialysis populations. We compared the value of cTnT, creatinine kinase (CK)-MB mass and myoglobin as mortality predictors in our hemodialysis patients and evaluated their relation to nutritional status.

Methods

A total of 118 hemodialysis patients were prospectively studied from January 2004 to April 2013. Clinical and laboratory evaluations during the 12-month baseline period included the history of IHD, signs of left ventricular hypertrophy (LVH), Kt/V and serum cardiac markers together with the percentage of body fat (%fat), mid-arm circumference (MAC), mid-arm muscle circumference (MAMC), triceps skinfold (TSF) and BMI.

Results

Underweight patients had significantly higher cTnT values (Mann-Whitney, p<0.05). Correlation analysis (Spearman) showed an inverse association between cTnT and TSF (ρ=-0.22, p<0.05), as well as between CK-MB mass and TSF (ρ=-0.26, p<0.01). In men cTnT also correlated inversely with %fat (ρ=-0.27, p<0.05) and BMI (ρ=-0.33, p<0.05). In addition, myoglobin was correlated significantly with MAC, MAMC and albumin. Among cardiac markers cTnT was the only independent variable predicting mortality (Multivariate Cox regression, HR=1.04 CI (1.01-1.07); p<0.01; measurement units 0.01 μg/L).

Conclusion

Troponin T and CK-MB mass were significantly elevated in the underweight patient group. Troponin T was the only independent cardiac marker predictor of all cause mortality in our hemodialysis patients."xsd:string
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http://purl.uniprot.org/citations/24846126http://purl.uniprot.org/core/author"Jovanovic D.B."xsd:string
http://purl.uniprot.org/citations/24846126http://purl.uniprot.org/core/author"Naumovic R.T."xsd:string
http://purl.uniprot.org/citations/24846126http://purl.uniprot.org/core/author"Simic-Ogrizovic S.P."xsd:string
http://purl.uniprot.org/citations/24846126http://purl.uniprot.org/core/author"Stankovic S.D.j."xsd:string
http://purl.uniprot.org/citations/24846126http://purl.uniprot.org/core/author"Stanojevic M.L.j."xsd:string
http://purl.uniprot.org/citations/24846126http://purl.uniprot.org/core/author"Stosovic M.D."xsd:string
http://purl.uniprot.org/citations/24846126http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24846126http://purl.uniprot.org/core/name"Ren Fail"xsd:string
http://purl.uniprot.org/citations/24846126http://purl.uniprot.org/core/pages"1060-1066"xsd:string
http://purl.uniprot.org/citations/24846126http://purl.uniprot.org/core/title"A comparison of markers of myocardial injury and their relation to nutritional parameters in hemodialysis patients."xsd:string
http://purl.uniprot.org/citations/24846126http://purl.uniprot.org/core/volume"36"xsd:string
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