| http://purl.uniprot.org/citations/24855000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24855000 | http://www.w3.org/2000/01/rdf-schema#comment | "The early mouse embryo undertakes two types of cell division: symmetric that gives rise to the trophectoderm and then placenta or asymmetric that gives rise to inner cells that generate the embryo proper. Although cell division orientation is important, the mechanism regulating it has remained unclear. Here, we identify the relationship between the plane of cell division and the position of the nucleus and go towards identifying the mechanism behind it. We first find that as the 8-cell embryo progresses through the cell cycle, the nuclei of most - but not all - cells move from apical to more basal positions, in a microtubule- and kinesin-dependent manner. We then find that all asymmetric divisions happen when nuclei are located basally and, in contrast, all cells, in which nuclei remain apical, divide symmetrically. To understand the potential mechanism behind this, we determine the effects of modulating expression of Cdx2, a transcription factor key for trophectoderm formation and cell polarity. We find that increased expression of Cdx2 leads to an increase in a number of apical nuclei, whereas down-regulation of Cdx2 leads to more nuclei moving basally, which explains a previously identified relationship between Cdx2 and cell division orientation. Finally, we show that down-regulation of aPKC, involved in cell polarity, decreases the number of apical nuclei and doubles the number of asymmetric divisions. These results suggest a model in which the mutual interdependence of Cdx2 and cell polarity affects the cytoskeleton-dependent positioning of nuclei and, in consequence, the plane of cell division in the early mouse embryo."xsd:string |
| http://purl.uniprot.org/citations/24855000 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2014.05.009"xsd:string |
| http://purl.uniprot.org/citations/24855000 | http://purl.uniprot.org/core/author | "Zernicka-Goetz M."xsd:string |
| http://purl.uniprot.org/citations/24855000 | http://purl.uniprot.org/core/author | "Ajduk A."xsd:string |
| http://purl.uniprot.org/citations/24855000 | http://purl.uniprot.org/core/author | "Biswas Shivhare S."xsd:string |
| http://purl.uniprot.org/citations/24855000 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24855000 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/24855000 | http://purl.uniprot.org/core/pages | "133-140"xsd:string |
| http://purl.uniprot.org/citations/24855000 | http://purl.uniprot.org/core/title | "The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo."xsd:string |
| http://purl.uniprot.org/citations/24855000 | http://purl.uniprot.org/core/volume | "392"xsd:string |
| http://purl.uniprot.org/citations/24855000 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24855000 |
| http://purl.uniprot.org/citations/24855000 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24855000 |
| http://purl.uniprot.org/uniprot/#_Q62074-mappedCitation-24855000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24855000 |
| http://purl.uniprot.org/uniprot/#_Q3UMD5-mappedCitation-24855000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24855000 |
| http://purl.uniprot.org/uniprot/#_Q3TJJ5-mappedCitation-24855000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24855000 |
| http://purl.uniprot.org/uniprot/#_Q3UGW9-mappedCitation-24855000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24855000 |
| http://purl.uniprot.org/uniprot/#_Q5DTK3-mappedCitation-24855000 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24855000 |
| http://purl.uniprot.org/uniprot/Q3UMD5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24855000 |
| http://purl.uniprot.org/uniprot/Q5DTK3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24855000 |
| http://purl.uniprot.org/uniprot/Q62074 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24855000 |
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| http://purl.uniprot.org/uniprot/Q3UGW9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24855000 |