| http://purl.uniprot.org/citations/24855944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24855944 | http://www.w3.org/2000/01/rdf-schema#comment | "TRPM7 is a ubiquitous ion channel and kinase, a unique "chanzyme," required for proper early embryonic development. It conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations and contains a functional serine/threonine kinase at its carboxyl terminus. Here, we show that in normal tissues and cell lines, the kinase is proteolytically cleaved from the channel domain in a cell-type-specific manner. These TRPM7 cleaved kinase fragments (M7CKs) translocate to the nucleus and bind multiple components of chromatin-remodeling complexes, including Polycomb group proteins. In the nucleus, the kinase phosphorylates specific serines/threonines of histones. M7CK-dependent phosphorylation of H3Ser10 at promoters of TRPM7-dependent genes correlates with their activity. We also demonstrate that cytosolic free [Zn(2+)] is TRPM7 dependent and regulates M7CK binding to transcription factors containing zinc-finger domains. These findings suggest that TRPM7-mediated modulation of intracellular Zn(2+) concentration couples ion-channel signaling to epigenetic chromatin covalent modifications that affect gene expression patterns. PAPERCLIP:"xsd:string |
| http://purl.uniprot.org/citations/24855944 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2014.03.046"xsd:string |
| http://purl.uniprot.org/citations/24855944 | http://purl.uniprot.org/core/author | "Clapham D.E."xsd:string |
| http://purl.uniprot.org/citations/24855944 | http://purl.uniprot.org/core/author | "Krapivinsky G."xsd:string |
| http://purl.uniprot.org/citations/24855944 | http://purl.uniprot.org/core/author | "Krapivinsky L."xsd:string |
| http://purl.uniprot.org/citations/24855944 | http://purl.uniprot.org/core/author | "Manasian Y."xsd:string |
| http://purl.uniprot.org/citations/24855944 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24855944 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/24855944 | http://purl.uniprot.org/core/pages | "1061-1072"xsd:string |
| http://purl.uniprot.org/citations/24855944 | http://purl.uniprot.org/core/title | "The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase."xsd:string |
| http://purl.uniprot.org/citations/24855944 | http://purl.uniprot.org/core/volume | "157"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A1E281-mappedCitation-24855944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24855944 |
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| http://purl.uniprot.org/uniprot/#_A0A494BAF6-mappedCitation-24855944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24855944 |