| http://purl.uniprot.org/citations/24861553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24861553 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488-47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10(-13)), ALDH2/MYL2 (rs671, P = 3.40 × 10(-11); rs12229654, P = 4.56 × 10(-9)), ITIH4 (rs2535633, P = 1.77 × 10(-10)) and NT5C2 (rs11191580, P = 3.83 × 10(-8)) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10(-8)) and an additional 14 at P < 1.0 × 10(-3) with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/ddu248"xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Akiyama K."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Cai Q."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "He J."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Kim E."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Kim Y.J."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "He M."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Kato N."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Kubo M."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Miki T."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Okada Y."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Qi L."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/24861553 | http://purl.uniprot.org/core/author | "Shin D.H."xsd:string |