| http://purl.uniprot.org/citations/24872409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24872409 | http://www.w3.org/2000/01/rdf-schema#comment | "Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, we report a previously uncharacterized role for Rab5a in the regulation of T-cell motility. We show that Rab5a physically associates with protein kinase Cϵ (PKCϵ) in migrating T-cells. After stimulation of T-cells through the integrin LFA-1 or the chemokine receptor CXCR4, Rab5a is phosphorylated on an N-terminal Thr-7 site by PKCϵ. Both Rab5a and PKCϵ dynamically interact at the centrosomal region of migrating cells, and PKCϵ-mediated phosphorylation on Thr-7 regulates Rab5a trafficking to the cell leading edge. Furthermore, we demonstrate that Rab5a Thr-7 phosphorylation is functionally necessary for Rac1 activation, actin rearrangement, and T-cell motility. We present a novel mechanism by which a PKCϵ-Rab5a-Rac1 axis regulates cytoskeleton remodeling and T-cell migration, both of which are central for the adaptive immune response."xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.545863"xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/author | "Long A."xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/author | "Kelleher D."xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/author | "Baier G."xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/author | "Verma N.K."xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/author | "Ong S.T."xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/author | "Fresser F."xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/author | "Fazil M.H."xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/author | "Freeley M."xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/author | "Skubis-Zegadlo J."xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/pages | "19420-19434"xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/title | "Phosphorylation of Rab5a protein by protein kinase Cϵ is crucial for T-cell migration."xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://purl.uniprot.org/core/volume | "289"xsd:string |
| http://purl.uniprot.org/citations/24872409 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24872409 |
| http://purl.uniprot.org/citations/24872409 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24872409 |
| http://purl.uniprot.org/uniprot/#_A0A0A1HAN9-mappedCitation-24872409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24872409 |
| http://purl.uniprot.org/uniprot/#_B2R9M7-mappedCitation-24872409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24872409 |
| http://purl.uniprot.org/uniprot/#_Q02156-mappedCitation-24872409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24872409 |
| http://purl.uniprot.org/uniprot/#_L7RTI5-mappedCitation-24872409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24872409 |
| http://purl.uniprot.org/uniprot/#_P20339-mappedCitation-24872409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24872409 |
| http://purl.uniprot.org/uniprot/#_Q53RT0-mappedCitation-24872409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24872409 |