| http://purl.uniprot.org/citations/24882358 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24882358 | http://www.w3.org/2000/01/rdf-schema#comment | "During the development of both vertebrates and invertebrates, neurons undergo a crucial remodeling process that is necessary for their new function. Neuronal remodeling is composed of two stages: first, axons and dendrites are pruned without the loss of the cell body; later, this process is most commonly followed by a regrowth step. Holometabolous insects like the fruitfly Drosophila exhibit striking differences between their larval and adult stages. These neuronal remodeling processes occur during metamorphosis, the period of transformation from a larva to an adult. All axon and dendrite pruning events ultimately depend on the EcR nuclear receptor. Its ligand, the steroid molting hormone ecdysone, binds to heteromeric receptors comprising the nuclear receptor ECR and USP, and this complex regulates target genes involved in neuronal remodeling. Here we review the nuclear receptor-mediated genetic control of the main neuronal remodeling events described so far in Drosophila. These events consist of neurite degeneration in the mushroom bodies (MBs: the brain memory center) and in the dendritic arborizing sensory neurons, of neurite retraction or small scale elimination in the thoracic ventral neurosecretory cells, in the olfactory circuits and in the neuromuscular junction. MB axon regrowth after pruning and the role of MB neuron remodeling in memory formation are also reviewed. This article is part of a Special Issue entitled: Nuclear receptors in animal development."xsd:string |
| http://purl.uniprot.org/citations/24882358 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbagrm.2014.05.024"xsd:string |
| http://purl.uniprot.org/citations/24882358 | http://purl.uniprot.org/core/author | "Boulanger A."xsd:string |
| http://purl.uniprot.org/citations/24882358 | http://purl.uniprot.org/core/author | "Dura J.M."xsd:string |
| http://purl.uniprot.org/citations/24882358 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/24882358 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/24882358 | http://purl.uniprot.org/core/pages | "187-195"xsd:string |
| http://purl.uniprot.org/citations/24882358 | http://purl.uniprot.org/core/title | "Nuclear receptors and Drosophila neuronal remodeling."xsd:string |
| http://purl.uniprot.org/citations/24882358 | http://purl.uniprot.org/core/volume | "1849"xsd:string |
| http://purl.uniprot.org/citations/24882358 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24882358 |
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