| http://purl.uniprot.org/citations/24887019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24887019 | http://www.w3.org/2000/01/rdf-schema#comment | "IntroductionBehçet's disease (BD) as systemic vasculitis of unknown etiology is associated with HLA-B*51 in European and Asian populations. HLA-A*26 was claimed as an additional BD susceptibility marker in Japanese and Greek patients. This study was performed to test for HLA associations in HLA-B*51 negative German and Turkish BD populations.MethodsIn total, 65 German and 46 Turkish patients lacking HLA-B*51 were analyzed in comparison to healthy HLA-B*51 negative Germans (n = 1500) and Turks (n = 130). HLA-A/B genotypes were determined by SSOP. P-values with correction for multiple testing (p(c)), χ2-test and odds ratio (OR) were used for statistical evaluation.ResultsHLA-A*26 was significantly more frequent in HLA-B*51-German patients [p(c) = 0.0076, OR = 3.23, 95% CI 1.63 to 6.39] than in respective controls. HLA-A*26 was also elevated in a smaller group of Turkish patients versus the controls. Significant association of HLA-Bw4 with isoleucine at amino-acid position 80 (HLA-Bw4-80I) was found in the HLA-B*51(-) German cohort of BD patients [p(c) = 0.0042, OR = 2.35, 95% CI 1.41 to 3.93) and in the Turkish patients in comparison to the respective controls [p = 0.025, OR = 2.17, 95% CI 1.09 to 4.31]. On the contrary, HLA-Bw4-80 T was reduced in both HLA-B*51(-) BD patient cohorts.ConclusionsThe study shows a significant association of HLA-Bw4-80I present on HLA-B*51 as well as on other B-locus molecules with BD. This indicates that distinctive Bw4 epitopes on HLA-B locus molecules could play a role in BD pathogenesis. The study also indicates an association with HLA-A*26 in German and Turkish BD patients as a genetic risk factor independent of HLA-B*51."xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.org/dc/terms/identifier | "doi:10.1186/ar4569"xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/author | "Momynaliev K.T."xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/author | "Kuranov A.B."xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/author | "Steiert I."xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/author | "Muller C.A."xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/author | "Kotter I."xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/author | "Abisheva S.T."xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/author | "Henes J.C."xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/author | "Riewerts F."xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/name | "Arthritis Res Ther"xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/pages | "R116"xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/title | "Behcet's disease in HLA-B*51 negative Germans and Turks shows association with HLA-Bw4-80I."xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/24887019 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24887019 |
| http://purl.uniprot.org/citations/24887019 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24887019 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-24887019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24887019 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-24887019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24887019 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-24887019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24887019 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-24887019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24887019 |
| http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-24887019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24887019 |
| http://purl.uniprot.org/uniprot/#_A0A068B112-mappedCitation-24887019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24887019 |
| http://purl.uniprot.org/uniprot/#_A0A068B116-mappedCitation-24887019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24887019 |