| http://purl.uniprot.org/citations/24895401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24895401 | http://www.w3.org/2000/01/rdf-schema#comment | "Actomyosin ring (AMR) contraction and the synthesis of an extracellular septum are interdependent pathways that mediate cytokinesis in the yeast Saccharomyces cerevisiae and other eukaryotes. How these interdependent pathways are physically connected is central for understanding cytokinesis. The yeast IQGAP (Iqg1p) belongs to the conserved AMR. The F-BAR-domain-containing protein Hof1p is a member of a complex that stimulates cell wall synthesis. We report here on the stepwise formation of a physical connection between both proteins. The C-terminal IQ-repeats of Iqg1p first bind to the essential myosin light chain before both proteins assemble with Hof1p into the Mlc1p-Iqg1p-Hof1p (MIH) bridge. Mutations in Iqg1p that disrupt the MIH complex alter Hof1p targeting to the AMR and impair AMR contraction. Epistasis analyses of two IQG1 alleles that are incompatible with formation of the MIH complex support the existence and functional significance of a large cytokinetic core complex. We propose that the MIH complex acts as hinge between the AMR and the proteins involved in cell wall synthesis and membrane attachment."xsd:string |
| http://purl.uniprot.org/citations/24895401 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.153429"xsd:string |
| http://purl.uniprot.org/citations/24895401 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/24895401 | http://purl.uniprot.org/core/author | "Tian C."xsd:string |
| http://purl.uniprot.org/citations/24895401 | http://purl.uniprot.org/core/author | "Johnsson N."xsd:string |
| http://purl.uniprot.org/citations/24895401 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24895401 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/24895401 | http://purl.uniprot.org/core/pages | "3614-3624"xsd:string |
| http://purl.uniprot.org/citations/24895401 | http://purl.uniprot.org/core/title | "Stepwise and cooperative assembly of a cytokinetic core complex in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/24895401 | http://purl.uniprot.org/core/volume | "127"xsd:string |
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| http://purl.uniprot.org/uniprot/Q05080#attribution-5BEAC0F4D780431DECE9DA6681B19CD0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24895401 |
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| http://purl.uniprot.org/uniprot/P53141#attribution-FC51CE88D4E9194A3F7D0C135F2E6FED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24895401 |
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