| http://purl.uniprot.org/citations/24896182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24896182 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional enhancers are crucial regulators of gene expression and animal development and the characterization of their genomic organization, spatiotemporal activities and sequence properties is a key goal in modern biology. Here we characterize the in vivo activity of 7,705 Drosophila melanogaster enhancer candidates covering 13.5% of the non-coding non-repetitive genome throughout embryogenesis. 3,557 (46%) candidates are active, suggesting a high density with 50,000 to 100,000 developmental enhancers genome-wide. The vast majority of enhancers display specific spatial patterns that are highly dynamic during development. Most appear to regulate their neighbouring genes, suggesting that the cis-regulatory genome is organized locally into domains, which are supported by chromosomal domains, insulator binding and genome evolution. However, 12 to 21 per cent of enhancers appear to skip non-expressed neighbours and regulate a more distal gene. Finally, we computationally identify cis-regulatory motifs that are predictive and required for enhancer activity, as we validate experimentally. This work provides global insights into the organization of an animal regulatory genome and the make-up of enhancer sequences and confirms and generalizes principles from previous studies. All enhancer patterns are annotated manually with a controlled vocabulary and all results are available through a web interface (http://enhancers.starklab.org), including the raw images of all microscopy slides for manual inspection at arbitrary zoom levels."xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature13395"xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/author | "Stark A."xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/author | "Dickson B.J."xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/author | "Pagani M."xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/author | "Schernhuber K."xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/author | "Kvon E.Z."xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/author | "Stampfel G."xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/author | "Yanez-Cuna J.O."xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/author | "Kazmar T."xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/pages | "91-95"xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/title | "Genome-scale functional characterization of Drosophila developmental enhancers in vivo."xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://purl.uniprot.org/core/volume | "512"xsd:string |
| http://purl.uniprot.org/citations/24896182 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24896182 |
| http://purl.uniprot.org/citations/24896182 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24896182 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KFQ1-mappedCitation-24896182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24896182 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KFS6-mappedCitation-24896182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24896182 |
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