| http://purl.uniprot.org/citations/24897500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24897500 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of the CD200 ligand-CD200 receptor (CD200-CD200R) inhibitory axis is highly important in controlling myeloid cell function. Since the activation of myeloid cells is crucial in arteriogenesis, we hypothesized that disruption of the CD200-CD200R axis promotes arteriogenesis in a murine hindlimb ischemia model. Female Cd200-/- and wildtype (C57Bl/6J) mice underwent unilateral femoral artery ligation. Perfusion recovery was monitored over 7 days using Laser-Doppler analysis and was increased in Cd200-/-mice at day 3 and 7 after femoral artery ligation, compared to wildtype. Histology was performed on hindlimb muscles at baseline, day 3 and 7 to assess vessel geometry and number and inflammatory cell influx. Vessel geometry in non-ischemic muscles was larger, and vessel numbers in ischemic muscles were increased in Cd200-/-mice compared to wildtype. Furthermore, T lymphocyte influx was increased in Cd200-/-compared to wildtype. CD200R agonist treatment was performed in male C57Bl/6J mice to validate the role of the CD200-CD200R axis in arteriogenesis. CD200R agonist treatment after unilateral femoral artery ligation resulted in a significant decrease in vessel geometry, perfusion recovery and T lymphocyte influx at day 7 compared to isotype treatment. In this study, we show a causal role for the CD200-CD200R inhibitory axis in arteriogenesis in a murine hindlimb ischemia model. Lack of CD200R signaling is accompanied by increased T lymphocyte recruitment to the collateral vasculature and results in enlargement of preexisting collateral arteries."xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0098820"xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/author | "Pasterkamp G."xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/author | "Boon L."xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/author | "Meyaard L."xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/author | "Westerlaken G.H."xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/author | "Hoefer I.E."xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/author | "Quax P.H."xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/author | "Rygiel T.P."xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/author | "van den Borne P."xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/author | "Hoogendoorn A."xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/pages | "e98820"xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/title | "The CD200-CD200 receptor inhibitory axis controls arteriogenesis and local T lymphocyte influx."xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24897500 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24897500 |
| http://purl.uniprot.org/citations/24897500 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24897500 |
| http://purl.uniprot.org/uniprot/#_E9PZI9-mappedCitation-24897500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24897500 |
| http://purl.uniprot.org/uniprot/#_A0A338P6B8-mappedCitation-24897500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24897500 |
| http://purl.uniprot.org/uniprot/#_E9QMY1-mappedCitation-24897500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24897500 |
| http://purl.uniprot.org/uniprot/#_O54901-mappedCitation-24897500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24897500 |
| http://purl.uniprot.org/uniprot/#_M0QWY6-mappedCitation-24897500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24897500 |
| http://purl.uniprot.org/uniprot/#_Q05D16-mappedCitation-24897500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24897500 |