| http://purl.uniprot.org/citations/24900560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24900560 | http://www.w3.org/2000/01/rdf-schema#comment | "A series of aryl hydroxamates recently have been disclosed as irreversible inhibitors of kynurenine amino transferase II (KAT II), an enzyme that may play a role in schizophrenia and other psychiatric and neurological disorders. The utilization of structure-activity relationships (SAR) in conjunction with X-ray crystallography led to the discovery of hydroxamate 4, a disubstituted analogue that has a significant potency enhancement due to a novel interaction with KAT II. The use of k inact/K i to assess potency was critical for understanding the SAR in this series and for identifying compounds with improved pharmacodynamic profiles."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.org/dc/terms/identifier | "doi:10.1021/ml300237v"xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Chang C."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Kim J.Y."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Pandit J."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Gan X."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Anderson M."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "James L.C."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Zawadzke L.E."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Strick C.A."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Fonseca K.R."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Verhoest P.R."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Evrard E."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Horner W."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Tuttle J.B."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Bechle B.M."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Dounay A.B."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "McAllister L.A."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Salafia M.A."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Campbell B.M."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Parikh V.D."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/author | "Rago B.J."xsd:string |
| http://purl.uniprot.org/citations/24900560 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |