| http://purl.uniprot.org/citations/24904088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24904088 | http://www.w3.org/2000/01/rdf-schema#comment | "Podocytes are terminally differentiated cells with an elaborate cytoskeleton and are critical components of the glomerular barrier. We identified a bHLH transcription factor, Tcf21, that is highly expressed in developing and mature podocytes. Because conventional Tcf21 knockout mice die in the perinatal period with major cardiopulmonary defects, we generated a conditional Tcf21 knockout mouse to explore the role of this transcription factor in podocytes in vivo. Tcf21 was deleted from podocytes and podocyte progenitors using podocin-cre (podTcf21) and wnt4-cre (wnt4creTcf21) driver strains, respectively. Loss of Tcf21 from capillary-loop stage podocytes (podTcf21) results in simplified glomeruli with a decreased number of endothelial and mesangial cells. By 5 weeks of age, 40% of podTcf21 mice develop massive proteinuria and lesions similar to FSGS. Notably, the remaining 60% of mice do not develop proteinuria even when aged to 8 months. By contrast, earlier deletion of Tcf21 from podocyte precursors (wnt4creTcf21) results in a profound developmental arrest of podocyte differentiation and renal failure in 100% of mice during the perinatal period. Taken together, our results demonstrate a critical role for Tcf21 in the differentiation and maintenance of podocytes. Identification of direct targets of this transcription factor may provide new therapeutic avenues for proteinuric renal disease, including FSGS."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2013121307"xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Ghosh A."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Scott R.P."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Dimke H."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Shan J."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Lewin M."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Miner J.H."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Quaggin S.E."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Onay T."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Binnie M."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Keir L.S."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Eremina V."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Maezawa Y."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Vainio S.J."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Jeansson M."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/author | "Maezawa Y.'"xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/pages | "2459-2470"xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/title | "Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS."xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/24904088 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24904088 |