| http://purl.uniprot.org/citations/24904090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24904090 | http://www.w3.org/2000/01/rdf-schema#comment | "Recombination signal binding protein for Ig-κJ region (RBP-J), the major downstream effector of Notch signaling, is necessary to maintain the number of renin-positive juxtaglomerular cells and the plasticity of arteriolar smooth muscle cells to re-express renin when homeostasis is threatened. We hypothesized that RBP-J controls a repertoire of genes that defines the phenotype of the renin cell. Mice bearing a bacterial artificial chromosome reporter with a mutated RBP-J binding site in the renin promoter had markedly reduced reporter expression at the basal state and in response to a homeostatic challenge. Mice with conditional deletion of RBP-J in renin cells had decreased expression of endocrine (renin and Akr1b7) and smooth muscle (Acta2, Myh11, Cnn1, and Smtn) genes and regulators of smooth muscle expression (miR-145, SRF, Nfatc4, and Crip1). To determine whether RBP-J deletion decreased the endowment of renin cells, we traced the fate of these cells in RBP-J conditional deletion mice. Notably, the lineage staining patterns in mutant and control kidneys were identical, although mutant kidneys had fewer or no renin-expressing cells in the juxtaglomerular apparatus. Microarray analysis of mutant arterioles revealed upregulation of genes usually expressed in hematopoietic cells. Thus, these results suggest that RBP-J maintains the identity of the renin cell by not only activating genes characteristic of the myo-endocrine phenotype but also, preventing ectopic gene expression and adoption of an aberrant phenotype, which could have severe consequences for the control of homeostasis."xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2013101045"xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/author | "Gomez R.A."xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/author | "Pentz E.S."xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/author | "Lin E."xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/author | "Medrano S."xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/author | "Gross K.W."xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/author | "Sequeira-Lopez M.L."xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/author | "Castellanos-Rivera R.M."xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/pages | "67-80"xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/title | "Recombination signal binding protein for Ig-kappaJ region regulates juxtaglomerular cell phenotype by activating the myo-endocrine program and suppressing ectopic gene expression."xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/24904090 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24904090 |
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