| http://purl.uniprot.org/citations/24905202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24905202 | http://www.w3.org/2000/01/rdf-schema#comment | "The host interferon (IFN) antiviral response involves a myriad of diverse biochemical pathways that disrupt virus replication cycles at many different levels. As a result, viruses have acquired and evolved genes that antagonize the host antiviral proteins. IFNs inhibit viral infections in part through the 2',5'-oligoadenylate (2-5A) synthetase (OAS)/RNase L pathway. OAS proteins are pathogen recognition receptors that exist at different basal levels in different cell types and that are IFN inducible. Upon activation by the pathogen-associated molecular pattern viral double-stranded RNA, certain OAS proteins synthesize 2-5A from ATP. 2-5A binds to the antiviral enzyme RNase L causing its dimerization and activation. Recently, disparate RNA viruses, group 2a betacoronaviruses, and group A rotaviruses, have been shown to produce proteins with 2',5'-phosphodiesterase (PDE) activities that eliminate 2-5A thereby evading the antiviral activity of the OAS/RNase L pathway. These viral proteins are members of the eukaryotic-viral LigT-like group of 2H phosphoesterases, so named for the presence of 2 conserved catalytic histidine residues. Here, we will review the biochemistry, biology, and implications of viral and cellular 2',5'-PDEs that degrade 2-5A. In addition, we discuss alternative viral and cellular strategies for limiting the activity of OAS/RNase L."xsd:string |
| http://purl.uniprot.org/citations/24905202 | http://purl.org/dc/terms/identifier | "doi:10.1089/jir.2014.0007"xsd:string |
| http://purl.uniprot.org/citations/24905202 | http://purl.uniprot.org/core/author | "Silverman R.H."xsd:string |
| http://purl.uniprot.org/citations/24905202 | http://purl.uniprot.org/core/author | "Weiss S.R."xsd:string |
| http://purl.uniprot.org/citations/24905202 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24905202 | http://purl.uniprot.org/core/name | "J Interferon Cytokine Res"xsd:string |
| http://purl.uniprot.org/citations/24905202 | http://purl.uniprot.org/core/pages | "455-463"xsd:string |
| http://purl.uniprot.org/citations/24905202 | http://purl.uniprot.org/core/title | "Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A."xsd:string |
| http://purl.uniprot.org/citations/24905202 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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