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http://purl.uniprot.org/citations/24905619http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24905619http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Previous studies investigating the association between interleukin 1β (IL-1β) and its receptor antagonist (IL-1RN) polymorphism and cervical cancer risk have reported controversial results. Thus, we examined these associations by performing meta-analyses.

Methods and materials

Fourteen studies testing the association between IL-1β and/or IL-1RN gene polymorphisms and cervical cancer were examined: 5 studies of IL-1β-511C/T, 3 studies of IL-1β-31T/C, and 6 studies of IL-1RN. Overall and ethnicity-specific summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for cervical cancer associated with these polymorphisms were estimated using fixed- and random-effects models. Heterogeneity and publication bias were evaluated.

Results

Meta-analysis of all 6 studies showed variant genotypes of IL-1RN to be associated with an elevated cervical cancer risk (RN2/RN2 vs RN1/RN1: OR, 2.64; 95% CI, 1.29-5.40; recessive: OR, 2.15; 95% CI, 1.06-4.38; dominant: OR, 1.60; 95% CI, 1.07-2.38). Combined analysis indicated that IL-1β-511C/T polymorphism was also associated with increased risk of cervical cancer (TT vs CC: OR, 1.56; 95% CI, 1.22-1.99; CT vs CC: OR, 1.61; 95% CI, 1.31-1.99; dominant: OR, 1.60; 95% CI, 1.31-1.95). No significant association of IL-1β-31T/C and cervical cancer risk was detected. There was no evidence of publication bias.

Conclusions

This meta-analysis suggested that the IL-1RN and IL-1β-511C/T polymorphisms may contribute to genetic susceptibility of cervical cancer. More studies are needed to further evaluate the role of the IL-1β-31T/C polymorphism in the etiology of cancer."xsd:string
http://purl.uniprot.org/citations/24905619http://purl.org/dc/terms/identifier"doi:10.1097/igc.0000000000000165"xsd:string
http://purl.uniprot.org/citations/24905619http://purl.uniprot.org/core/author"Chen J."xsd:string
http://purl.uniprot.org/citations/24905619http://purl.uniprot.org/core/author"Hu G."xsd:string
http://purl.uniprot.org/citations/24905619http://purl.uniprot.org/core/author"Xie G."xsd:string
http://purl.uniprot.org/citations/24905619http://purl.uniprot.org/core/author"Wu S."xsd:string
http://purl.uniprot.org/citations/24905619http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/24905619http://purl.uniprot.org/core/name"Int J Gynecol Cancer"xsd:string
http://purl.uniprot.org/citations/24905619http://purl.uniprot.org/core/pages"984-990"xsd:string
http://purl.uniprot.org/citations/24905619http://purl.uniprot.org/core/title"Interleukin 1beta and interleukin 1 receptor antagonist gene polymorphisms and cervical cancer: a meta-analysis."xsd:string
http://purl.uniprot.org/citations/24905619http://purl.uniprot.org/core/volume"24"xsd:string
http://purl.uniprot.org/citations/24905619http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24905619
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