| http://purl.uniprot.org/citations/24906005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24906005 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial dysfunction has been implicated in the pathophysiology of various cardiovascular diseases. CRIF1 is a protein present in the mitochondria associated with large mitoribosomal subunits, and CRIF1 knockdown induces mitochondrial dysfunction and promotes ROS production. p66shc is a redox enzyme implicated in mitochondrial ROS generation and translation of oxidative signals and, therefore, is a key factor for oxidative stress in endothelial cells. In this study, we investigated whether mitochondrial dysfunction induced by CRIF1 knockdown induces p66shc stimulation and plays any role in mitochondrial dysfunction-induced endothelial activation. Knockdown of CRIF1 decreased the expression of mitochondrial oxidative phosphorylation (OXPHOS) complexes I, III and IV, leading to increased mitochondrial ROS (mtROS) and hyperpolarization of the mitochondrial membrane potential. Knockdown of CRIF1 also stimulated phosphorylation of p66shc and increased cytosolic ROS in endothelial cells. Furthermore, the expression of vascular cell adhesion molecule-1 and endoplasmic reticulum stress proteins were increased upon CRIF1 knockdown in endothelial cells. However, p66shc knockdown blunted the alteration in mitochondrial dynamics and ROS production in CRIF1 knockdown endothelial cells. In addition, p66shc knockdown reduced the CRIF1 knockdown-induced increases in adhesion between monocytes and endothelial cells. Taken together, these results suggest that CRIF1 knockdown partially induces endothelial activation via increased ROS production and phosphorylation of p66shc."xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0098670"xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/author | "Song H.J."xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/author | "Park J.B."xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/author | "Kwon S.K."xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/author | "Shong M."xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/author | "Kim C.S."xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/author | "Irani K."xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/author | "Jung S.B."xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/author | "Jeon B.H."xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/author | "Nagar H."xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/pages | "e98670"xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/title | "CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation."xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24906005 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24906005 |
| http://purl.uniprot.org/citations/24906005 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24906005 |
| http://purl.uniprot.org/uniprot/#_B4DL02-mappedCitation-24906005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24906005 |
| http://purl.uniprot.org/uniprot/#_P98083-mappedCitation-24906005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24906005 |
| http://purl.uniprot.org/uniprot/#_P29353-mappedCitation-24906005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24906005 |
| http://purl.uniprot.org/uniprot/#_Q59HB0-mappedCitation-24906005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24906005 |
| http://purl.uniprot.org/uniprot/#_Q7LAX7-mappedCitation-24906005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24906005 |
| http://purl.uniprot.org/uniprot/#_Q9CR59-mappedCitation-24906005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24906005 |