| http://purl.uniprot.org/citations/24907648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24907648 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional activation is typically associated with increased acetylation of promoter histones. However, this paradigm does not apply to transcriptional activation of all genes. In this study we have characterized a group of genes that are repressed by histone acetylation. These histone hypoacetylation-activated genes (HHAAG) are normally repressed during exponential growth, when the cellular level of acetyl-CoA is high and global histone acetylation is also high. The HHAAG are induced during diauxic shift, when the levels of acetyl-CoA and global histone acetylation decrease. The histone hypoacetylation-induced activation of HHAAG is independent of Msn2/Msn4. The repression of HSP12, one of the HHAAG, is associated with well-defined nucleosomal structure in the promoter region, while histone hypoacetylation-induced activation correlates with delocalization of positioned nucleosomes or with reduced nucleosome occupancy. Correspondingly, unlike the majority of yeast genes, HHAAG are transcriptionally upregulated when expression of histone genes is reduced. Taken together, these results suggest a model in which histone acetylation is required for proper positioning of promoter nucleosomes and repression of HHAAG."xsd:string |
| http://purl.uniprot.org/citations/24907648 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbagrm.2014.05.029"xsd:string |
| http://purl.uniprot.org/citations/24907648 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/24907648 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/24907648 | http://purl.uniprot.org/core/author | "Pemberton L.F."xsd:string |
| http://purl.uniprot.org/citations/24907648 | http://purl.uniprot.org/core/author | "Mehrotra S."xsd:string |
| http://purl.uniprot.org/citations/24907648 | http://purl.uniprot.org/core/author | "Vancura A."xsd:string |
| http://purl.uniprot.org/citations/24907648 | http://purl.uniprot.org/core/author | "Galdieri L."xsd:string |
| http://purl.uniprot.org/citations/24907648 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24907648 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/24907648 | http://purl.uniprot.org/core/pages | "751-763"xsd:string |
| http://purl.uniprot.org/citations/24907648 | http://purl.uniprot.org/core/title | "Histone hypoacetylation-activated genes are repressed by acetyl-CoA- and chromatin-mediated mechanism."xsd:string |
| http://purl.uniprot.org/citations/24907648 | http://purl.uniprot.org/core/volume | "1839"xsd:string |
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