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Aims

To investigate the relationship between physiological serum total bilirubin concentrations and serum C-peptide levels in Korean patients with Type 2 diabetes.

Methods

A total of 588 patients with Type 2 diabetes were investigated in this cross-sectional study. Fasting C-peptide level, 2-h postprandial C-peptide level and ΔC-peptide (postprandial C-peptide minus fasting C-peptide) level were measured in all patients.

Results

Fasting C-peptide level, postprandial C-peptide level and ΔC-peptide level tended to be higher in patients with higher bilirubin concentrations. Partial correlation analysis showed that serum bilirubin levels were significantly correlated with fasting C-peptide level (r = 0.159, P < 0.001), postprandial C-peptide level (r = 0.209, P < 0.001) and ΔC-peptide level (r = 0.186, P < 0.001) after adjustment for other covariates. In the multivariate model, the association between serum bilirubin concentrations and serum C-peptide levels remained significant after adjustment for confounding factors including age, gender, familial diabetes, hypertension, hyperlipidaemia, BMI, HbA1c , duration of diabetes and associated liver function tests (fasting C-peptide level: β = 0.083, P = 0.041; postprandial C-peptide level: β = 0.106, P = 0.005; ΔC-peptide level: β = 0.096, P = 0.015, respectively).

Conclusions

Serum bilirubin concentrations within the physiological range were positively associated with serum C-peptide levels in patients with Type 2 diabetes."xsd:string
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http://purl.uniprot.org/citations/24910105http://purl.uniprot.org/core/author"Chung M.Y."xsd:string
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http://purl.uniprot.org/citations/24910105http://purl.uniprot.org/core/title"Serum bilirubin concentrations are positively associated with serum C-peptide levels in patients with Type 2 diabetes."xsd:string
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