| http://purl.uniprot.org/citations/24912570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24912570 | http://www.w3.org/2000/01/rdf-schema#comment | "HIP-55 (HPK1-interacting protein of 55 kDa, also named DBNL, SH3P7, and mAbp1) is a multidomain adaptor protein that is critical for organ development and the immune response. Here, we report the coupling of HIP-55 to cell growth control through its 14-3-3-binding phospho-Ser/Thr-sensor sites. Using affinity chromatography, we found HIP-55 formed a complex with 14-3-3 proteins, revealing a new node in phospho-Ser/Thr-mediated signaling networks. In addition, we demonstrated that HIP-55 is required for proper cell growth control. Enforced HIP-55 expression promoted proliferation, colony formation, migration, and invasion of lung cancer cells while silencing of HIP-55 reversed these effects. Importantly, HIP-55 was found to be upregulated in lung cancer cell lines and in tumor tissues of lung cancer patients. Upregulated HIP-55 was required to promote the growth of tumors in a xenograft animal model. However, tumors with S269A/T291A-mutated HIP-55, which ablates 14-3-3 binding, exhibited significantly reduced sizes, supporting a vital role of the HIP-55/14-3-3 protein interaction node in transmitting oncogenic signals. Mechanistically, HIP-55-mediated tumorigenesis activity appears to be in part mediated by antagonizing the tumor suppressor function of HPK1. Thus, the HIP-55-mediated oncogenic pathway, through S269/T291, may be exploited for the development of new therapeutic strategies."xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.1900"xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/author | "Du Y."xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/author | "Fu H."xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/author | "Shi Z."xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/author | "Han Q."xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/author | "Li Z.'"xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/author | "Park H.R."xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/author | "Khuri F.R."xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/author | "Pham C.D."xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/pages | "3197-3209"xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/title | "Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through Ser269/Thr291-phospho-sensor motifs."xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/24912570 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24912570 |
| http://purl.uniprot.org/citations/24912570 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24912570 |
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| http://purl.uniprot.org/uniprot/#_B4DUF9-mappedCitation-24912570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24912570 |