| http://purl.uniprot.org/citations/24913268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24913268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24913268 | http://www.w3.org/2000/01/rdf-schema#comment | "Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential anti-malarial therapies. Antibiotics that inhibit protein translation are promising candidates for repositioning. We have solved the cryo-EM structure of the cytoplasmic ribosome from the human malaria parasite, Plasmodium falciparum, in complex with emetine at 3.2 Å resolution. Emetine is an anti-protozoan drug used in the treatment of ameobiasis that also displays potent anti-malarial activity. Emetine interacts with the E-site of the ribosomal small subunit and shares a similar binding site with the antibiotic pactamycin, thereby delivering its therapeutic effect by blocking mRNA/tRNA translocation. As the first cryo-EM structure that visualizes an antibiotic bound to any ribosome at atomic resolution, this establishes cryo-EM as a powerful tool for screening and guiding the design of drugs that target parasite translation machinery."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.03080"xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.03080"xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.org/dc/terms/identifier | "doi:10.7554/eLife.03080"xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Brown A."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Brown A."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Wong W."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Wong W."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Baum J."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Baum J."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Hanssen E."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Hanssen E."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Bai X.C."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Bai X.C."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Condron M."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Condron M."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Fernandez I.S."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Fernandez I.S."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Scheres S.H."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Scheres S.H."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Tan Y.H."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/author | "Tan Y.H."xsd:string |
| http://purl.uniprot.org/citations/24913268 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |