| http://purl.uniprot.org/citations/24915078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24915078 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclophilin D (CypD) is a key mitochondrial target for amyloid-β-induced mitochondrial and synaptic dysfunction and is considered a potential drug target for Alzheimer's disease. The high-resolution crystal structures of primitive orthorhombic (CypD-o) and primitive tetragonal (CypD-t) forms have been determined to 1.45 and 0.85 Å resolution, respectively, and are nearly identical structurally. Although an isomorphous structure of CypD-t has previously been reported, the structure reported here was determined at atomic resolution, while CypD-o represents a new crystal form for this protein. In addition, each crystal form contains a PEG 400 molecule bound to the same region along with a second PEG 400 site in CypD-t which occupies the cyclosporine A inhibitor binding site of CypD. Highly precise structural information for CypD should be extremely useful for discerning the detailed interaction of small molecules, particularly drugs and/or inhibitors, bound to CypD. The 0.85 Å resolution structure of CypD-t is the highest to date for any CypD structure."xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.org/dc/terms/identifier | "doi:10.1107/s2053230x14009480"xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/author | "Battaile K.P."xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/author | "Lovell S."xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/author | "Carlson E.A."xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/author | "Valasani K.R."xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/author | "Bisson A."xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/author | "ShiDu Yan S."xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/name | "Acta Crystallogr F Struct Biol Commun"xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/pages | "717-722"xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/title | "High-resolution crystal structures of two crystal forms of human cyclophilin D in complex with PEG 400 molecules."xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/24915078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24915078 |
| http://purl.uniprot.org/citations/24915078 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24915078 |
| http://purl.uniprot.org/uniprot/#_P30405-mappedCitation-24915078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24915078 |
| http://purl.uniprot.org/uniprot/P30405 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24915078 |