| http://purl.uniprot.org/citations/24920488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24920488 | http://www.w3.org/2000/01/rdf-schema#comment | "Extramedullary involvement (EMI) is a factor that defines prognosis of acute lymphoblastic leukemia; however, the molecular mechanism(s) remain elusive. Here, we show that CD7 promotes EMI of the human B-cell acute lymphoblastic leukemia cell line Tanoue. The Tanoue cell line expressing firefly luciferase, Luc-Tanoue, was transplanted into non-obese diabetic/severe combined immunodeficient mice, and cells infiltrated into the brain were cultured ex vivo. This process was repeated 4 times to obtain the highly invasive line Luc-Tanoue-F4. Comparison of the global gene expression signatures of Luc-Tanoue-F4 and Luc-Tanoue indicated that the CD7 gene showed the largest increase in expression among EMI-related genes in Luc-Tanoue-F4 cells. Overexpression of CD7 in Tanoue enhanced cell invasiveness. Among cell migration, proliferation, adhesion and protease activity, only cell adhesiveness showed enhancement in Luc-Tanoue-F4. Expression of the intracellular domain, but not the extracellular domain, of CD7 enhanced cell adhesiveness. Luc-Tanoue-F4 showed a higher level of integrin β2 expression; overexpression of CD7 induced the expression of integrin β2 in Luc-Tanoue. These results show that CD7 induces integrin β2 and enhances cell adhesiveness and invasiveness in Tanoue cells. This study highlights the role of the CD7/integrin β2 axis as a critical pathway in the process of EMI of human B-cell acute lymphoblastic leukemia."xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijo.2014.2492"xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://purl.uniprot.org/core/author | "Watanabe N."xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://purl.uniprot.org/core/author | "Kobayashi D."xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://purl.uniprot.org/core/author | "Kondoh T."xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://purl.uniprot.org/core/author | "Yanagihara N."xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://purl.uniprot.org/core/author | "Kuribayashi K."xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24920488 | http://purl.uniprot.org/core/name | "Int J Oncol"xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://purl.uniprot.org/core/pages | "1073-1081"xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://purl.uniprot.org/core/title | "CD7 promotes extramedullary involvement of the B-cell acute lymphoblastic leukemia line Tanoue by enhancing integrin beta2-dependent cell adhesiveness."xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/24920488 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24920488 |
| http://purl.uniprot.org/citations/24920488 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24920488 |
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| http://purl.uniprot.org/uniprot/#_A0A024D9S0-mappedCitation-24920488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24920488 |
| http://purl.uniprot.org/uniprot/#_A0A024DAE5-mappedCitation-24920488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24920488 |
| http://purl.uniprot.org/uniprot/#_A0A024DAF4-mappedCitation-24920488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24920488 |
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| http://purl.uniprot.org/uniprot/#_A0A024DAS5-mappedCitation-24920488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24920488 |
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| http://purl.uniprot.org/uniprot/#_A0A024DBF8-mappedCitation-24920488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24920488 |