| http://purl.uniprot.org/citations/24928431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24928431 | http://www.w3.org/2000/01/rdf-schema#comment | "The miR-17∼92 cluster family is composed of three members encoding microRNAs that share seed sequences. To assess their role in cerebellar and medulloblastoma (MB) development, we deleted the miR-17∼92 cluster family in Nestin-positive neural progenitors and in mice heterozygous for the Sonic Hedgehog (SHH) receptor Patched 1 (Ptch1(+/-)). We show that mice in which we conditionally deleted the miR-17∼92 cluster (miR-17∼92(floxed/floxed); Nestin-Cre(+)) alone or together with the complete loss of the miR-106b∼25 cluster (miR-106b∼25(-/-)) were born alive but with small brains and reduced cerebellar foliation. Remarkably, deletion of the miR-17∼92 cluster abolished the development of SHH-MB in Ptch1(+/-) mice. Using an orthotopic transplant approach, we showed that granule neuron precursors (GNPs) purified from the cerebella of postnatal day 7 (P7) Ptch1(+/-); miR-106b∼25(-/-) mice and overexpressing Mycn induced MBs in the cortices of naïve recipient mice. In contrast, GNPs purified from the cerebella of P7 Ptch1(+/-); miR-17∼92(floxed/floxed); Nestin-Cre(+) animals and overexpressing Mycn failed to induce tumors in recipient animals. Taken together, our findings demonstrate that the miR-17∼92 cluster is dispensable for cerebellar development, but required for SHH-MB development."xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.org/dc/terms/identifier | "doi:10.1242/bio.20146734"xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/author | "Lee Y."xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/author | "McKinnon P.J."xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/author | "Ayrault O."xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/author | "Roussel M.F."xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/author | "Zindy F."xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/author | "Ventura A."xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/author | "Kawauchi D."xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/author | "Ben Merzoug L."xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/name | "Biol Open"xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/pages | "597-605"xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/title | "Role of the miR-17~92 cluster family in cerebellar and medulloblastoma development."xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/24928431 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24928431 |
| http://purl.uniprot.org/citations/24928431 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24928431 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVW7-mappedCitation-24928431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24928431 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX7-mappedCitation-24928431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24928431 |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ4-mappedCitation-24928431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24928431 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU51-mappedCitation-24928431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24928431 |
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| http://purl.uniprot.org/uniprot/#_A2A4W9-mappedCitation-24928431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24928431 |