| http://purl.uniprot.org/citations/24935457 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24935457 | http://www.w3.org/2000/01/rdf-schema#comment | "Thymocyte development requires the coordinated input of signals that originate from numerous cell surface molecules. Although the majority of thymocyte signal-initiating receptors are lineage-specific, most trigger 'ubiquitous' downstream signaling pathways. T-lineage-specific receptors are coupled to these signaling pathways by lymphocyte-restricted adapter molecules. We and others recently identified a new putative adapter protein, Themis1, whose expression is largely restricted to the T lineage. Mice lacking Themis1 exhibit a severe block in thymocyte development and a striking paucity of mature T cells revealing a critical role for Themis1 in T-cell maturation. Themis1 orthologs contain three conserved domains: a proline-rich region (PRR) that binds to the ubiquitous cytosolic adapter Grb2, a nuclear localization sequence (NLS), and two copies of a novel cysteine-containing globular (CABIT) domain. In the present study, we evaluated the functional importance of each of these motifs by retroviral reconstitution of Themis1(-/-) progenitor cells. The results demonstrate an essential requirement for the PRR and NLS motifs but not the conserved CABIT cysteines for Themis1 function."xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.org/dc/terms/identifier | "doi:10.1038/icb.2014.43"xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/author | "Love P.E."xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/author | "El-Khoury D."xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/author | "Zvezdova E."xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/author | "Barr V."xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/author | "Akpan I."xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/author | "Samelson L."xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/name | "Immunol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/pages | "721-728"xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/title | "In vivo functional mapping of the conserved protein domains within murine Themis1."xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://purl.uniprot.org/core/volume | "92"xsd:string |
| http://purl.uniprot.org/citations/24935457 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24935457 |
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