http://purl.uniprot.org/citations/24935562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/24935562 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundEpidermal growth factor receptor (EGFR) mutations and echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) define specific molecular subsets of lung adenocarcinomas with distinct clinical features. Our purpose was to analyze clinical features and prognostic value of EGFR gene mutations and the EML4-ALK fusion gene in lung adenocarcinoma.Patients and methodsEGFR gene mutations and the EML4-ALK fusion gene were detected in 92 lung adenocarcinoma patients in China. Tumor marker levels before first treatment were measured by electrochemiluminescence immunoassay.ResultsEGFR mutations were found in 40.2% (37/92) of lung adenocarcinoma patients, being identified at high frequencies in never-smokers (48.3% vs. 26.5% in smokers; P=0.040) and in patients with abnormal serum carcinoembryonic antigen (CEA) levels before the initial treatment (58.3% vs. 28.6%, P=0.004). Multivariate analysis revealed that a higher serum CEA level before the initial treatment was independently associated with EGFR gene mutations (95%CI: 1.476~11.343, P=0.007). We also identified 8 patients who harbored the EML4-ALK fusion gene (8.7%, 8/92). In concordance with previous reports, younger age was a clinical feature for these (P=0.008). Seven of the positive cases were never smokers, and no coexistence with EGFR mutation was discovered. In addition, the frequency of the EML4-ALK fusion gene among patients with a serum CEA concentration below 5 ng/ml seemed to be higher than patients with a concentration over 5 ng/ml (P=0.021). No significant difference was observed for time to progression and overall survival between EML4-ALK-positive group and EML4-ALK-negative group or between patients with and without an EGFR mutation.ConclusionsThe serum CEA level before the initial treatment may be helpful in screening population for EGFR mutations or EML4-ALK fusion gene presence in lung adenocarcinoma patients."xsd:string |
http://purl.uniprot.org/citations/24935562 | http://purl.org/dc/terms/identifier | "doi:10.7314/apjcp.2014.15.9.3927"xsd:string |
http://purl.uniprot.org/citations/24935562 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
http://purl.uniprot.org/citations/24935562 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
http://purl.uniprot.org/citations/24935562 | http://purl.uniprot.org/core/author | "Chen X.B."xsd:string |
http://purl.uniprot.org/citations/24935562 | http://purl.uniprot.org/core/author | "Wang W.T."xsd:string |
http://purl.uniprot.org/citations/24935562 | http://purl.uniprot.org/core/author | "Qin J.J."xsd:string |
http://purl.uniprot.org/citations/24935562 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
http://purl.uniprot.org/citations/24935562 | http://purl.uniprot.org/core/name | "Asian Pac J Cancer Prev"xsd:string |
http://purl.uniprot.org/citations/24935562 | http://purl.uniprot.org/core/pages | "3927-3932"xsd:string |
http://purl.uniprot.org/citations/24935562 | http://purl.uniprot.org/core/title | "Serum carcinoembryonic antigen levels before initial treatment are associated with EGFR mutations and EML4- ALK fusion gene in lung adenocarcinoma patients."xsd:string |
http://purl.uniprot.org/citations/24935562 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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