| http://purl.uniprot.org/citations/24937178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24937178 | http://www.w3.org/2000/01/rdf-schema#comment | "Macrophages play a critical role in the host immune response against mycobacterial infection. Our previous study has demonstrated that microRNA-155 (miR-155), one of the most important small non-coding RNAs in the immune system, promotes oxygen-independent mycobacterial killing in macrophages. However, little is known regarding the role of miR-155 in modulating oxygen-dependent mycobactericidal response in macrophages, including the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). In the present study, we demonstrated that miR-155 was increased in macrophages after Mycobacterium bovis bacille Calmette-Guérin (BCG) infection. Moreover, the BCG-induced upregulation of miR-155 in macrophages was dependent on TLR2, NF-κB and JNK signaling pathways. More importantly, our study explored that miR-155 significantly elevated ROS production in macrophages, although miR-155 had no influence on the inducible nitric oxide synthase (iNOS) expression or nitric oxide (NO) production. In addition, our study demonstrated that miR-155 repressed the expression of src homology 2 (SH2) containing inositol 5-phosphatase1 (SHIP1), and knockdown of SHIP1 greatly increased ROS production in BCG-infected macrophages. Collectively, these data indicate that miR-155 modulates ROS but not RNS production by targeting SHIP1, which may provide a better understanding of the host anti-mycobacterial response."xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2014.05.012"xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/author | "Feng L."xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/author | "Wu M."xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/author | "Yang K."xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/author | "Zhan X."xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/author | "Wen J."xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/author | "Li M.'"xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/pages | "29-36"xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/title | "MicroRNA-155 induction by Mycobacterium bovis BCG enhances ROS production through targeting SHIP1."xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/24937178 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24937178 |
| http://purl.uniprot.org/citations/24937178 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24937178 |
| http://purl.uniprot.org/uniprot/#_E9Q752-mappedCitation-24937178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24937178 |
| http://purl.uniprot.org/uniprot/#_F7BZA7-mappedCitation-24937178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24937178 |
| http://purl.uniprot.org/uniprot/#_G3X8Y8-mappedCitation-24937178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24937178 |
| http://purl.uniprot.org/uniprot/#_Q811T5-mappedCitation-24937178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24937178 |
| http://purl.uniprot.org/uniprot/#_Q9QZC9-mappedCitation-24937178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24937178 |
| http://purl.uniprot.org/uniprot/#_Q9QZD0-mappedCitation-24937178 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24937178 |