| http://purl.uniprot.org/citations/24944246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24944246 | http://www.w3.org/2000/01/rdf-schema#comment | "Inducible gene expression, which requires chromatin remodeling on gene promoters, underlies the epigenetically inherited differentiation program of most immune cells. However, chromatin-mediated mechanisms that underlie these events in T regulatory cells remain to be fully characterized. Here, we report that inducibility of FOXP3, a key transcription factor for the development of T regulatory cells, depends upon Kruppel-like factor 10 (KLF10) interacting with two antagonistic histone-modifying systems. We utilized chromatin immunoprecipitation, genome-integrated reporter assays, and functional domain KLF10 mutant proteins, to characterize reciprocal interactions between this transcription factor and either the Sin3-histone deacetylase complex or the histone acetyltransferase, p300/CBP-associated factor (PCAF). We characterize a Sin3-interacting repressor domain on the NH2 terminus of KLF10, which works to limit the activating function of this transcription factor. Indeed, inactivation of this Sin3-interacting domain renders KLF10 able to physically associate with PCAF as to induce FOXP3 gene transcription. We show that this biochemical data derived from studying our genome-integrated reporter cell system are recapitulated in primary murine lymphocytes. Collectively, these results advance our understanding of how a single transcription factor, namely KLF10, functions as a toggle to integrate antagonistic signals regulating FOXP3 and, thus, immune activation."xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpregu.00085.2014"xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/author | "Xiong Y."xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/author | "Khanna S."xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/author | "Svingen P.A."xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/author | "Urrutia R.A."xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/author | "Smyrk T.C."xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/author | "Faubion W.A. Jr."xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/author | "Dave M."xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/author | "Lomberk G.A."xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/author | "Sarmento O.O."xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/name | "Am J Physiol Regul Integr Comp Physiol"xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/pages | "R608-20"xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/title | "Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene."xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://purl.uniprot.org/core/volume | "307"xsd:string |
| http://purl.uniprot.org/citations/24944246 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24944246 |
| http://purl.uniprot.org/citations/24944246 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24944246 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRQ2-mappedCitation-24944246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24944246 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRS7-mappedCitation-24944246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24944246 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-24944246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24944246 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC46-mappedCitation-24944246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24944246 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPZ3-mappedCitation-24944246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24944246 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQ59-mappedCitation-24944246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24944246 |