| http://purl.uniprot.org/citations/24948803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24948803 | http://www.w3.org/2000/01/rdf-schema#comment | "During synaptic development, presynaptic differentiation occurs as an intrinsic property of axons to form specialized areas of plasma membrane [active zones (AZs)] that regulate exocytosis and endocytosis of synaptic vesicles. Genetic and biochemical studies in vertebrate and invertebrate model systems have identified a number of proteins involved in AZ assembly. However, elucidating the molecular events of AZ assembly in a spatiotemporal manner remains a challenge. Syd-1 (synapse defective-1) and Liprin-α have been identified as two master organizers of AZ assembly. Genetic and imaging analyses in invertebrates show that Syd-1 works upstream of Liprin-α in synaptic assembly through undefined mechanisms. To understand molecular pathways downstream of Liprin-α, we performed a proteomic screen of Liprin-α-interacting proteins in Drosophila brains. We identify Drosophila protein phosphatase 2A (PP2A) regulatory subunit B' [Wrd (Well Rounded)] as a Liprin-α-interacting protein, and we demonstrate that it mediates the interaction of Liprin-α with PP2A holoenzyme and the Liprin-α-dependent synaptic localization of PP2A. Interestingly, loss of function in syd-1, liprin-α, or wrd shares a common defect in which a portion of synaptic vesicles, dense-core vesicles, and presynaptic cytomatrix proteins ectopically accumulate at the distal, but not proximal, region of motoneuron axons. Strong genetic data show that a linear syd-1/liprin-α/wrd pathway in the motoneuron antagonizes glycogen synthase kinase-3β kinase activity to prevent the ectopic accumulation of synaptic materials. Furthermore, we provide data suggesting that the syd-1/liprin-α/wrd pathway stabilizes AZ specification at the nerve terminal and that such a novel function is independent of the roles of syd-1/liprin-α in regulating the morphology of the T-bar structural protein BRP (Bruchpilot)."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.0409-14.2014"xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/author | "Tian X."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/author | "Zhu M."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/author | "Sigrist S.J."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/author | "Levitan E.S."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/author | "Bohme M.A."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/author | "Goettfert F."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/author | "Wichmann C."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/author | "Bulgari D."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/pages | "8474-8487"xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/title | "Drosophila Syd-1, liprin-alpha, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons."xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/24948803 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24948803 |
| http://purl.uniprot.org/citations/24948803 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24948803 |
| http://purl.uniprot.org/uniprot/Q9V9S7#attribution-90A736125926419ECF5161D40722252D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24948803 |
| http://purl.uniprot.org/uniprot/Q9VM93#attribution-90A736125926419ECF5161D40722252D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24948803 |
| http://purl.uniprot.org/uniprot/Q0KI58#attribution-90A736125926419ECF5161D40722252D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24948803 |
| http://purl.uniprot.org/uniprot/Q5BIJ2#attribution-90A736125926419ECF5161D40722252D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24948803 |
| http://purl.uniprot.org/uniprot/Q9VEC6#attribution-90A736125926419ECF5161D40722252D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24948803 |