| http://purl.uniprot.org/citations/24951820 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24951820 | http://www.w3.org/2000/01/rdf-schema#comment | "Whereas NO is known to regulate T cell responses, its role in regulating B cell responses remains unclear. Previous studies suggested that inducible NO synthase 2 (NOS2/iNOS) is required for normal IgA Ab responses but inhibits antiviral IgG2a Ab responses. In this study we used NOS2(-/-) mice to determine the role of NO in T cell-dependent and T cell-independent (TI)-2 Ab responses. Whereas T cell-dependent Ab responses were only modestly increased in NOS2(-/-) mice, IgM and IgG3 Ab responses as well as marginal zone B cell plasma cell numbers and peritoneal B1b B cells were significantly elevated after immunization with the TI-2 Ag 4-hydroxy-3-nitrophenyl acetyl (NP)-Ficoll. The elevated TI-2 responses in NOS2(-/-) mice were accompanied by significant increases in serum levels of BAFF/BLyS and by increases in BAFF-producing Ly6C(hi) inflammatory monocytes and monocyte-derived dendritic cells (DCs), suggesting that NO normally inhibits BAFF expression. Indeed, we found that NOS2(-/-) DCs produced more BAFF than did wild-type DCs, and addition of a NO donor to NOS2(-/-) DCs reduced BAFF production. Bone marrow chimeric mice that lack NOS2 in either nonhematopoietic or hematopoietic cells had intermediate IgM and IgG3 Ab responses after NP-Ficoll immunization, suggesting that NOS2 from both hematopoietic and nonhematopoietic sources regulates TI-2 Ab responses. Similar to NOS2(-/-) mice, depletion of Ly6C(hi) inflammatory monocytes and monocyte-derived DCs enhanced NP-specific IgM and IgG3 responses to NP-Ficoll. Thus, NO produced by inflammatory monocytes and their derivative DC subsets plays an important role in regulating BAFF production and TI-2 Ab responses."xsd:string |
| http://purl.uniprot.org/citations/24951820 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1303158"xsd:string |
| http://purl.uniprot.org/citations/24951820 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/24951820 | http://purl.uniprot.org/core/author | "Hohl T.M."xsd:string |
| http://purl.uniprot.org/citations/24951820 | http://purl.uniprot.org/core/author | "Clark E.A."xsd:string |
| http://purl.uniprot.org/citations/24951820 | http://purl.uniprot.org/core/author | "Draves K.E."xsd:string |
| http://purl.uniprot.org/citations/24951820 | http://purl.uniprot.org/core/author | "Giordano D."xsd:string |
| http://purl.uniprot.org/citations/24951820 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24951820 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24951820 | http://purl.uniprot.org/core/pages | "1110-1120"xsd:string |
| http://purl.uniprot.org/citations/24951820 | http://purl.uniprot.org/core/title | "Nitric oxide regulates BAFF expression and T cell-independent antibody responses."xsd:string |
| http://purl.uniprot.org/citations/24951820 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/24951820 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24951820 |
| http://purl.uniprot.org/citations/24951820 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24951820 |
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