| http://purl.uniprot.org/citations/24956034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24956034 | http://www.w3.org/2000/01/rdf-schema#comment | "Using a comprehensive microarray database of human gene expression, we identified that in mammals, a secreted protein known as isthmin 1 (ISM1) is expressed in skin, mucosal tissues, and selected lymphocyte populations. ISM1 was originally identified in Xenopus brain during development, and it encodes a predicted ∼50-kDa protein containing a signal peptide, a thrombospondin domain, and an adhesion-associated domain. We confirmed the pattern of expression of ISM1 in both human and mouse tissues. ISM1 is expressed by DX5(+) lung lymphocytes that include NK and NKT-like cells, and is also expressed by some CD4(+) T cells upon activation but its expression increases significantly when CD4(+) T cells were polarized to the Th17 lineage in vitro. The presence of IFN-γ during CD4(+) T cell polarization inhibits ISM1 expression. Given that ISM1 has been reported to have anti-angiogenic properties, these observations suggest that ISM1 is a mediator of lymphocyte effector functions and may participate in both innate and acquired immune responses."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.org/dc/terms/identifier | "doi:10.1089/jir.2013.0137"xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/author | "Martinez C."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/author | "Zlotnik A."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/author | "Robinson O."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/author | "Hevezi P."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/author | "Homey B."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/author | "Burkhardt A.M."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/author | "Maravillas-Montero J.L."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/author | "Gerber P.A."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/author | "Buhren B.A."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/author | "Valle-Rios R."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/name | "J Interferon Cytokine Res"xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/pages | "795-801"xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/title | "Isthmin 1 is a secreted protein expressed in skin, mucosal tissues, and NK, NKT, and th17 cells."xsd:string |
| http://purl.uniprot.org/citations/24956034 | http://purl.uniprot.org/core/volume | "34"xsd:string |
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