| http://purl.uniprot.org/citations/24956222 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24956222 | http://www.w3.org/2000/01/rdf-schema#comment | "Azadirachtin is a botanical insecticide that affects various biological processes. The effects of azadirachtin on the digital gene expression profile and growth inhibition in Drosophila larvae have not been investigated. In this study, we applied high-throughput sequencing technology to detect the differentially expressed genes of Drosophila larvae regulated by azadirachtin. A total of 15,322 genes were detected, and 28 genes were found to be significantly regulated by azadirachtin. Biological process and pathway analysis showed that azadirachtin affected starch and sucrose metabolism, defense response, signal transduction, instar larval or pupal development, and chemosensory behavior processes. The genes regulated by azadirachtin were mainly enriched in starch and sucrose metabolism. This study provided a general digital gene expression profile of dysregulated genes in response to azadirachtin and showed that azadirachtin provoked potent growth inhibitory effects in Drosophila larvae by regulating the genes of cuticular protein, amylase, and odorant-binding protein. Finally, we propose a potential mechanism underlying the dysregulation of the insulin/insulin-like growth factor signaling pathway by azadirachtin."xsd:string |
| http://purl.uniprot.org/citations/24956222 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jbiotec.2014.06.014"xsd:string |
| http://purl.uniprot.org/citations/24956222 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/24956222 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/24956222 | http://purl.uniprot.org/core/author | "Yuan M."xsd:string |
| http://purl.uniprot.org/citations/24956222 | http://purl.uniprot.org/core/author | "Jin X."xsd:string |
| http://purl.uniprot.org/citations/24956222 | http://purl.uniprot.org/core/author | "Lai D."xsd:string |
| http://purl.uniprot.org/citations/24956222 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24956222 | http://purl.uniprot.org/core/name | "J Biotechnol"xsd:string |
| http://purl.uniprot.org/citations/24956222 | http://purl.uniprot.org/core/pages | "51-56"xsd:string |
| http://purl.uniprot.org/citations/24956222 | http://purl.uniprot.org/core/title | "Gene expression profile change and growth inhibition in Drosophila larvae treated with azadirachtin."xsd:string |
| http://purl.uniprot.org/citations/24956222 | http://purl.uniprot.org/core/volume | "185"xsd:string |
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