| http://purl.uniprot.org/citations/24957743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24957743 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24957743 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinases are zinc-dependent endopeptidases conserved throughout the animal kingdom which primarily degrade components of the extracellular matrix. In the nematode Caenorhabditis elegans, the zinc matrix metalloproteinase (ZMP-2) was demonstrated to increase resistance versus heat and bacterial pathogens. Here, we show that the survival reducing activities caused by the knockdown of zmp-2 in C. elegans essentially requires the presence of vitellogenin-6, a protein homologous to mammalian apolipoprotein B, and RME-2, a receptor mediating endocytosis of cholesterol particles. Measurements of reactive oxygen species inside and outside C. elegans revealed that knockdown of zmp-2 causes a prooxidative extracellular mileu which is a prerequisite for the reduction of survival. Interestingly, RNAi for the foxo transcription factor daf-16 completely prevented those survival reducing effects of zmp-2 RNAi, and RNAi in mutants of the steroid signalling pathway revealed that DAF-16 acts by inhibition of DAF-9 and DAF-12. In conclusion, our study demonstrates survival reducing activities caused by the functional loss of ZMP-2 in C. elegans. Those effects are mediated by the transport of oxidized cholesterol adducts which then trigger the inhibition of DAF-9 and DAF-12 through the activation of DAF-16."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12263-014-0414-6"xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12263-014-0414-6"xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/author | "Boll M."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/author | "Boll M."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/author | "Fischer M."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/author | "Fischer M."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/author | "Fitzenberger E."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/author | "Fitzenberger E."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/author | "Kull R."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/author | "Kull R."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/author | "Wenzel U."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/author | "Wenzel U."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/name | "Genes Nutr."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/name | "Genes Nutr."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/pages | "414"xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/pages | "414"xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/title | "The zinc matrix metalloproteinase ZMP-2 increases survival of Caenorhabditis elegans through interference with lipoprotein absorption."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/title | "The zinc matrix metalloproteinase ZMP-2 increases survival of Caenorhabditis elegans through interference with lipoprotein absorption."xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24957743 | http://purl.uniprot.org/core/volume | "9"xsd:string |