| http://purl.uniprot.org/citations/24957822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24957822 | http://www.w3.org/2000/01/rdf-schema#comment | "Streptogramin antibiotics are divided into types A and B, which in combination can act synergistically. We compared the molecular interactions of the streptogramin combinations Synercid (type A, dalfopristin; type B, quinupristin) and NXL 103 (type A, flopristin; type B, linopristin) with the Escherichia coli 70S ribosome by X-ray crystallography. We further analyzed the activity of the streptogramin components individually and in combination. The streptogramin A and B components in Synercid and NXL 103 exhibit synergistic antimicrobial activity against certain pathogenic bacteria. However, in transcription-coupled translation assays, only combinations that include dalfopristin, the streptogramin A component of Synercid, show synergy. Notably, the diethylaminoethylsulfonyl group in dalfopristin reduces its activity but is the basis for synergy in transcription-coupled translation assays before its rapid hydrolysis from the depsipeptide core. Replacement of the diethylaminoethylsulfonyl group in dalfopristin by a nonhydrolyzable group may therefore be beneficial for synergy. The absence of general streptogramin synergy in transcription-coupled translation assays suggests that the synergistic antimicrobial activity of streptogramins can occur independently of the effects of streptogramin on translation."xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://purl.org/dc/terms/identifier | "doi:10.1128/aac.03389-14"xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://purl.uniprot.org/core/author | "Cate J.H."xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://purl.uniprot.org/core/author | "Olivier N.B."xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://purl.uniprot.org/core/author | "Noeske J."xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://purl.uniprot.org/core/author | "Zambrowski M."xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://purl.uniprot.org/core/author | "Giacobbe R.A."xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24957822 | http://purl.uniprot.org/core/name | "Antimicrob Agents Chemother"xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://purl.uniprot.org/core/pages | "5269-5279"xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://purl.uniprot.org/core/title | "Synergy of streptogramin antibiotics occurs independently of their effects on translation."xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://purl.uniprot.org/core/volume | "58"xsd:string |
| http://purl.uniprot.org/citations/24957822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24957822 |
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