| http://purl.uniprot.org/citations/24958900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24958900 | http://www.w3.org/2000/01/rdf-schema#comment | "The glycoprotein milk fat globule-epidermal growth factor factor 8 (MFG-E8) is expressed in several tissues and mediates diverse homeostatic functions. However, whether it plays a role in bone homeostasis has not been established. In this study, we show for the first time, to our knowledge, that osteoclasts express and are regulated by MFG-E8. Bone marrow-derived osteoclast precursors from MFG-E8-deficient (Mfge8(-/-)) mice underwent increased receptor activator of NF-κB ligand-induced osteoclastogenesis, leading to enhanced resorption pit formation compared with wild-type controls. Consistently, exogenously added MFG-E8 inhibited receptor activator of NF-κB ligand-induced osteoclastogenesis from mouse or human osteoclast precursors. Upon induction of experimental periodontitis, an oral inflammatory disease characterized by loss of bone support of the dentition, Mfge8(-/-) mice exhibited higher numbers of osteoclasts and more bone loss than did wild-type controls. Accordingly, local microinjection of anti-MFG-E8 mAb exacerbated periodontal bone loss in wild-type mice. Conversely, microinjection of MFG-E8 inhibited bone loss in experimental mouse periodontitis. In comparison with wild-type controls, Mfge8(-/-) mice also experienced >60% more naturally occurring chronic periodontal bone loss. In conclusion, MFG-E8 is a novel homeostatic regulator of osteoclasts that could be exploited therapeutically to treat periodontitis and perhaps other immunological disorders associated with inflammatory bone loss."xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1400970"xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://purl.uniprot.org/core/author | "Shin J."xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://purl.uniprot.org/core/author | "Hajishengallis G."xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://purl.uniprot.org/core/author | "Chavakis T."xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://purl.uniprot.org/core/author | "Udey M.C."xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://purl.uniprot.org/core/author | "Hosur K."xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24958900 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://purl.uniprot.org/core/pages | "1383-1391"xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://purl.uniprot.org/core/title | "Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8."xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/24958900 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24958900 |
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| http://purl.uniprot.org/uniprot/#_B3KTQ2-mappedCitation-24958900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24958900 |
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