| http://purl.uniprot.org/citations/24962333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24962333 | http://www.w3.org/2000/01/rdf-schema#comment | "Mice deficient in Latent TGFβ Binding Protein 4 (Ltbp4) display a defect in lung septation and elastogenesis. The lung septation defect is normalized by genetically decreasing TGFβ2 levels. However, the elastic fiber assembly is not improved in Tgfb2(-/-) ;Ltbp4S(-/-) compared to Ltbp4S(-/-) lungs. We found that decreased levels of TGFβ1 or TGFβ3 did not improve lung septation indicating that the TGFβ isoform elevated in Ltbp4S(-/-) lungs is TGFβ2. Expression of a form of Ltbp4 that could not bind latent TGFβ did not affect lung phenotype indicating that normal lung development does not require the formation of LTBP4-latent TGFβ complexes. Therefore, the change in TGFβ-level in the lungs is not directly related to Ltbp4 deficiency but probably is a consequence of changes in the extracellular matrix. Interestingly, combination of the Ltbp4S(-/-) mutation with a fibulin-5 null mutant in Fbln5(-/-) ;Ltbp4S(-/-) mice improves the lung septation compared to Ltbp4S(-/-) lungs. Large globular elastin aggregates characteristic for Ltbp4S(-/-) lungs do not form in Fbln5(-/-) ;Ltbp4S(-/-) lungs and EM studies showed that elastic fibers in Fbln5(-/-) ;Ltbp4S(-/-) lungs resemble those found in Fbln5(-/-) mice. These results are consistent with a role for TGFβ2 in lung septation and for Ltbp4 in regulating fibulin-5 dependent elastic fiber assembly."xsd:string |
| http://purl.uniprot.org/citations/24962333 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.24704"xsd:string |
| http://purl.uniprot.org/citations/24962333 | http://purl.uniprot.org/core/author | "Dabovic B."xsd:string |
| http://purl.uniprot.org/citations/24962333 | http://purl.uniprot.org/core/author | "Davis E.C."xsd:string |
| http://purl.uniprot.org/citations/24962333 | http://purl.uniprot.org/core/author | "Rifkin D.B."xsd:string |
| http://purl.uniprot.org/citations/24962333 | http://purl.uniprot.org/core/author | "Robertson I.B."xsd:string |
| http://purl.uniprot.org/citations/24962333 | http://purl.uniprot.org/core/author | "Zilberberg L."xsd:string |
| http://purl.uniprot.org/citations/24962333 | http://purl.uniprot.org/core/author | "Vassallo M."xsd:string |
| http://purl.uniprot.org/citations/24962333 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/24962333 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/24962333 | http://purl.uniprot.org/core/pages | "226-236"xsd:string |
| http://purl.uniprot.org/citations/24962333 | http://purl.uniprot.org/core/title | "Function of latent TGFbeta binding protein 4 and fibulin 5 in elastogenesis and lung development."xsd:string |
| http://purl.uniprot.org/citations/24962333 | http://purl.uniprot.org/core/volume | "230"xsd:string |
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