| http://purl.uniprot.org/citations/24963139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24963139 | http://www.w3.org/2000/01/rdf-schema#comment | "Binding of antigen to the B cell antigen receptor (BCR) initiates a multitude of events resulting in B cell activation. How the BCR becomes signaling-competent upon antigen binding is still a matter of controversy. Using a high-resolution proximity ligation assay (PLA) to monitor the conformation of the BCR and its interactions with co-receptors at a 10-20 nm resolution, we provide direct evidence for the opening of BCR dimers during B cell activation. We also show that upon binding Syk opens the receptor by an inside-out signaling mechanism that amplifies BCR signaling. Furthermore, we found that on resting B cells, the coreceptor CD19 is in close proximity with the IgD-BCR and on activated B cells with the IgM-BCR, indicating nanoscale reorganization of receptor clusters during B cell activation.DOI: http://dx.doi.org/10.7554/eLife.02069.001."xsd:string |
| http://purl.uniprot.org/citations/24963139 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.02069"xsd:string |
| http://purl.uniprot.org/citations/24963139 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/24963139 | http://purl.uniprot.org/core/author | "Reth M."xsd:string |
| http://purl.uniprot.org/citations/24963139 | http://purl.uniprot.org/core/author | "Hobeika E."xsd:string |
| http://purl.uniprot.org/citations/24963139 | http://purl.uniprot.org/core/author | "Klasener K."xsd:string |
| http://purl.uniprot.org/citations/24963139 | http://purl.uniprot.org/core/author | "Maity P.C."xsd:string |
| http://purl.uniprot.org/citations/24963139 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24963139 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/24963139 | http://purl.uniprot.org/core/pages | "e02069"xsd:string |
| http://purl.uniprot.org/citations/24963139 | http://purl.uniprot.org/core/title | "B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk."xsd:string |
| http://purl.uniprot.org/citations/24963139 | http://purl.uniprot.org/core/volume | "3"xsd:string |
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