| http://purl.uniprot.org/citations/24968734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24968734 | http://www.w3.org/2000/01/rdf-schema#comment | "There are scarce reports regarding a functional prognostic value of thyroid-stimulating autoantibody (TSAb) levels using a thyroid-stimulating hormone receptor chimera (Mc4) in Graves' disease (GD) in iodine sufficient area. The aim of this study was to investigate whether Mc4-TSAb can predict GD remission/relapse after antithyroid drug (ATD) treatment and to compare Mc4-TSAb with a binding assay using M22 monoclonal antibody (M22-TRAb) in GD patients. We retrospectively reviewed the results of M22-TRAb and Mc4-TSAb in GD patients treated with ATD for 12 months. GD patients who underwent ATD treatment for at least 12 months were included. We compared the predictive values of M22-TRAb and Mc4-TSAb for GD remission and relapse. Of the 92 patients, 60 (65.2%) achieved remission and 32 (34.8%) relapsed within 12 months. In receiver operating characteristic analysis, there were no significant differences in the area under the curves (AUCs) between Mc4-TSAb [AUC=0.79 (95% CI 0.69-0.89)] and M22-TRAb [AUC=0.69 (95% CI 0.58-0.81)]. The optimal predictive cut-off values of M22-TRAb and Mc4-TSAb were 2.23 IU/L and 230%, respectively. At a high Mc4-TSAb cut-off, the better specificity of 85.0% and positive predictive value (PPV) of 69.0% were shown compared with those at the best cut-off for M22-TRAb. In conclusion, a high cut-off for an Mc4 assay may improve the predictive value of relapse with superior specificity and PPV compared with M22-TRAb in treated GD."xsd:string |
| http://purl.uniprot.org/citations/24968734 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12020-014-0325-8"xsd:string |
| http://purl.uniprot.org/citations/24968734 | http://purl.uniprot.org/core/author | "Lee E.J."xsd:string |
| http://purl.uniprot.org/citations/24968734 | http://purl.uniprot.org/core/author | "Hwang S."xsd:string |
| http://purl.uniprot.org/citations/24968734 | http://purl.uniprot.org/core/author | "Shin D.Y."xsd:string |
| http://purl.uniprot.org/citations/24968734 | http://purl.uniprot.org/core/author | "Song M.K."xsd:string |
| http://purl.uniprot.org/citations/24968734 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/24968734 | http://purl.uniprot.org/core/name | "Endocrine"xsd:string |
| http://purl.uniprot.org/citations/24968734 | http://purl.uniprot.org/core/pages | "89-95"xsd:string |
| http://purl.uniprot.org/citations/24968734 | http://purl.uniprot.org/core/title | "High cut-off value of a chimeric TSH receptor (Mc4)-based bioassay may improve prediction of relapse in Graves' disease for 12 months."xsd:string |
| http://purl.uniprot.org/citations/24968734 | http://purl.uniprot.org/core/volume | "48"xsd:string |
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