DESCRIBE <http://purl.uniprot.org/citations/24969979>

Subject	Predicate	Object
http://purl.uniprot.org/citations/24969979	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24969979	http://www.w3.org/2000/01/rdf-schema#comment	" Purpose To investigate influencing factors of β-cells differentiation and microenvironment in embryonic development and regeneration, in order to conduct therapeutic efforts to broaden β-cells mass in diabetes. Materials and methods The expression of Ngn3 (Neurogenin-3) and microenvironment of β-cells differentiation during embryonic pancreas development at 4-12 weeks of gestation and regeneration after pancreatic islet injure observed by immunohistochemical staining. Results The results showed that the expression of Ngn3 not only in pancreas development but also in β-cells regeneration in rat diabetic model (DM) by streptozotocin (STZ) treatment. Pancreatic mesenchymal tissue always accompanied by islet cells differentiation and there is a short expression of Ngn3 occurrence before all islet cell types differentiated from pancreatic epithelium. The expression of Ngn3 including ectopic expression also appearance in β-cells injured rat pancreas. In addition, there are some Nestin-positive cells where located in pancreatic duct, islets and mesenchyme were detected in DM. Double immunostaining witness Brdu/Ngn3-positive cells was only in pancreatic mesenchyme after β-cells injure. Conclusions Our data demonstrated the expression of transcription factor Ngn3 and pancreatic mesenchymal microenvironment are important and necessary to promote pancreatic progenitors differentiated to islet cells regardless of pancreatic development or islets regeneration."xsd:string
http://purl.uniprot.org/citations/24969979	http://purl.uniprot.org/core/author	"Du Z."xsd:string
http://purl.uniprot.org/citations/24969979	http://purl.uniprot.org/core/author	"Wang Y."xsd:string
http://purl.uniprot.org/citations/24969979	http://purl.uniprot.org/core/author	"Zhang X."xsd:string
http://purl.uniprot.org/citations/24969979	http://purl.uniprot.org/core/author	"Yang K."xsd:string
http://purl.uniprot.org/citations/24969979	http://purl.uniprot.org/core/date	"2014"xsd:gYear
http://purl.uniprot.org/citations/24969979	http://purl.uniprot.org/core/name	"Rom J Morphol Embryol"xsd:string
http://purl.uniprot.org/citations/24969979	http://purl.uniprot.org/core/pages	"305-311"xsd:string
http://purl.uniprot.org/citations/24969979	http://purl.uniprot.org/core/title	"Short-reactivation of neurogenin-3 and mesenchymal microenvironment is require for beta-cells differentiation during fetal pancreas development and islet regeneration."xsd:string
http://purl.uniprot.org/citations/24969979	http://purl.uniprot.org/core/volume	"55"xsd:string
http://purl.uniprot.org/citations/24969979	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/24969979
http://purl.uniprot.org/citations/24969979	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/24969979
http://purl.uniprot.org/uniprot/#_F7EPK2-mappedCitation-24969979	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24969979
http://purl.uniprot.org/uniprot/#_E0X9P2-mappedCitation-24969979	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24969979
http://purl.uniprot.org/uniprot/#_O08718-mappedCitation-24969979	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24969979
http://purl.uniprot.org/uniprot/#_Q9Y4Z2-mappedCitation-24969979	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/24969979
http://purl.uniprot.org/uniprot/E0X9P2	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/24969979
http://purl.uniprot.org/uniprot/Q9Y4Z2	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/24969979
http://purl.uniprot.org/uniprot/F7EPK2	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/24969979
http://purl.uniprot.org/uniprot/O08718	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/24969979