| http://purl.uniprot.org/citations/24970086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24970086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24970086 | http://www.w3.org/2000/01/rdf-schema#comment | "Dynamin superfamily molecular motors use guanosine triphosphate (GTP) as a source of energy for membrane-remodeling events. We found that knockdown of nucleoside diphosphate kinases (NDPKs) NM23-H1/H2, which produce GTP through adenosine triphosphate (ATP)-driven conversion of guanosine diphosphate (GDP), inhibited dynamin-mediated endocytosis. NM23-H1/H2 localized at clathrin-coated pits and interacted with the proline-rich domain of dynamin. In vitro, NM23-H1/H2 were recruited to dynamin-induced tubules, stimulated GTP-loading on dynamin, and triggered fission in the presence of ATP and GDP. NM23-H4, a mitochondria-specific NDPK, colocalized with mitochondrial dynamin-like OPA1 involved in mitochondria inner membrane fusion and increased GTP-loading on OPA1. Like OPA1 loss of function, silencing of NM23-H4 but not NM23-H1/H2 resulted in mitochondrial fragmentation, reflecting fusion defects. Thus, NDPKs interact with and provide GTP to dynamins, allowing these motor proteins to work with high thermodynamic efficiency."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1253768"xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1253768"xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Shen Q."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Shen Q."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Schlattner U."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Schlattner U."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Lacombe M.L."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Lacombe M.L."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Lascu I."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Lascu I."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Raposo G."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Raposo G."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Roux A."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Roux A."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Chavrier P."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Chavrier P."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Montagnac G."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Montagnac G."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Polo S."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "Polo S."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "van der Bliek A.M."xsd:string |
| http://purl.uniprot.org/citations/24970086 | http://purl.uniprot.org/core/author | "van der Bliek A.M."xsd:string |