| http://purl.uniprot.org/citations/24970360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24970360 | http://www.w3.org/2000/01/rdf-schema#comment | "Osteoblasts produce various types of cytokines under pathological conditions and control osteoclast differentiation. Tumor necrosis factor-α (TNF-α) has been demonstrated to exert complex effects in osteoblasts under local inflammatory conditions, including in periodontal and periapical diseases. Interleukin-34 (IL-34) has been recently identified as a novel regulatory factor for the differentiation and function of osteoclasts. The present study provides the first evidence, to the best of our knowledge, that the expression of IL-34 is induced by TNF-α through nuclear factor-κB (NF-κB) activation in MC3T3-E1 osteoblastic cells. TNF-α induced IL-34 expression in a dose- and time-dependent manner. Immunocytochemistry with an NF-κB antibody demonstrated that NF-κB was mainly localized in the cytoplasm of the untreated MC3T3-E1 cells. Rapid translocation of NF-κB from the cytoplasm to the nucleus was observed in the cells treated with TNF-α for 15 min. Translocation and transcriptional activity of NF-κB were also determined by western blotting and a luciferase reporter assay, respectively. Pretreatment with 100 µM CAPE, an inhibitor of NF-κB, significantly inhibited TNF-α-induced IL-34 expression. These results indicate that TNF-α induces IL-34 expression via NF-κB in osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://purl.org/dc/terms/identifier | "doi:10.3892/mmr.2014.2353"xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://purl.uniprot.org/core/author | "Guo J."xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://purl.uniprot.org/core/author | "Haneji T."xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://purl.uniprot.org/core/author | "Qiu L."xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://purl.uniprot.org/core/author | "Yang D."xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://purl.uniprot.org/core/author | "Okamura H."xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24970360 | http://purl.uniprot.org/core/name | "Mol Med Rep"xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://purl.uniprot.org/core/pages | "1371-1376"xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://purl.uniprot.org/core/title | "Tumor necrosis factor-alpha induces interleukin-34 expression through nuclear factor‑kappaB activation in MC3T3-E1 osteoblastic cells."xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/24970360 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24970360 |
| http://purl.uniprot.org/citations/24970360 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24970360 |
| http://purl.uniprot.org/uniprot/#_Q8R1R4-mappedCitation-24970360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24970360 |
| http://purl.uniprot.org/uniprot/Q8R1R4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24970360 |