| http://purl.uniprot.org/citations/24970808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24970808 | http://www.w3.org/2000/01/rdf-schema#comment | "microRNAs, frequently deregulated in human cancer, have been implicated in the progression of hepatocarcinogenesis. Here, we show that microRNA (miR)-137 is significantly down-regulated in hepatocellular carcinoma (HCC). Its decreased expression is associated with vein invasion, incomplete Involucrum, and distant metastasis. Multivariate analysis suggests that miR-137 is an independent indicator for poor survival. We next show that over-expression of miR-137 suppresses cell proliferation, migration and invasion in vitro. Conversely, miR-137 inhibition promotes HCC cell growth. We also identify AKT2 as a key target of miR-137 in this context. Statistical data reveal a reverse correlation of AKT2 and miR-137 expression in HCC patients. Silencing of AKT2 phenotypically copied miR-137-induced phenotypes, whereas re-expression of AKT2 reversed the suppressive effects of miR-137. Further investigations showed that miR-137 exerted its anti-tumour activity via inhibiting the AKT2/mTOR pathway. Moreover, we demonstrate that FoxD3 directly binds to the promoter of miR-137 and activates its transcription. In vivo studies confirm that FoxD3-regulated miR-137 inhibited HCC growth and metastasis via targeting AKT2. Together, our findings indicate that miR-137 is a valuable biomarker for HCC prognosis and the FoxD3/miR-137/AKT2 regulatory network plays an important role in HCC progression."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.2089"xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/author | "Hu W."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/author | "Yang Y.Z."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/author | "Lu S.X."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/author | "Liu L.L."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/author | "Yun J.P."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/author | "Luo R.Z."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/author | "Zhang C.Z."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/author | "Li L.Z."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/pages | "5113-5124"xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/title | "FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2."xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/24970808 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24970808 |
| http://purl.uniprot.org/citations/24970808 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24970808 |
| http://purl.uniprot.org/uniprot/#_A0A0U4CQG9-mappedCitation-24970808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24970808 |
| http://purl.uniprot.org/uniprot/#_B4DG79-mappedCitation-24970808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24970808 |
| http://purl.uniprot.org/uniprot/#_B3KP61-mappedCitation-24970808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24970808 |
| http://purl.uniprot.org/uniprot/#_B7Z8Z9-mappedCitation-24970808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24970808 |
| http://purl.uniprot.org/uniprot/#_P31751-mappedCitation-24970808 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24970808 |