| http://purl.uniprot.org/citations/24975845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24975845 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial dysfunction in intestinal epithelial cells (IEC) is thought to precede the onset of inflammatory bowel diseases (IBD). Expression of Prohibitin 1 (PHB), a mitochondrial protein required for optimal electron transport chain (ETC) activity, is decreased in mucosal biopsies during active and inactive IBD. In addition to its activities as a transcription factor, Signal Transducer and Activator of Transcription 3 (Stat3) resides in the mitochondria of cells where phosphorylation at S727 is required for optimal ETC activity and protects against stress-induced mitochondrial dysfunction. Here, we show that PHB overexpression protects against mitochondrial stress and apoptosis of cultured IECs induced by TNFα, which is a pro-inflammatory cytokine involved in IBD pathogenesis. Expression of pS727-Stat3 dominant negative eliminates protection by PHB against TNFα-induced mitochondrial stress and apoptosis. PHB interacts with pS727-Stat3 in the mitochondria of cultured IECs and in colonic epithelium from wild-type mice. Our data suggest a protective role of PHB that is dependent on pS727-Stat3 to prevent mitochondrial dysfunction in IECs. Reduced levels of PHB during IBD may be an underlying factor promoting mitochondrial dysfunction of the intestinal epithelium."xsd:string |
| http://purl.uniprot.org/citations/24975845 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2014.06.006"xsd:string |
| http://purl.uniprot.org/citations/24975845 | http://purl.uniprot.org/core/author | "Han J."xsd:string |
| http://purl.uniprot.org/citations/24975845 | http://purl.uniprot.org/core/author | "Yu C."xsd:string |
| http://purl.uniprot.org/citations/24975845 | http://purl.uniprot.org/core/author | "Souza R.F."xsd:string |
| http://purl.uniprot.org/citations/24975845 | http://purl.uniprot.org/core/author | "Theiss A.L."xsd:string |
| http://purl.uniprot.org/citations/24975845 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24975845 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/24975845 | http://purl.uniprot.org/core/pages | "2086-2095"xsd:string |
| http://purl.uniprot.org/citations/24975845 | http://purl.uniprot.org/core/title | "Prohibitin 1 modulates mitochondrial function of Stat3."xsd:string |
| http://purl.uniprot.org/citations/24975845 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/24975845 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24975845 |
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| http://purl.uniprot.org/uniprot/#_Q13022-mappedCitation-24975845 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24975845 |
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