| http://purl.uniprot.org/citations/24982181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24982181 | http://www.w3.org/2000/01/rdf-schema#comment | "Ablation of a single miRNA gene rarely leads to a discernable developmental phenotype in mice, in some cases because of compensatory effects by other functionally related miRNAs. Here, we report that simultaneous inactivation of two functionally related miRNA clusters (miR-34b/c and miR-449) encoding five miRNAs (miR-34b, miR-34c, miR-449a, miR-449b, and miR-449c) led to sexually dimorphic, partial perinatal lethality, growth retardation, and infertility. These developmental defects correlated with the dysregulation of ∼ 240 target genes, which are mainly involved in three major cellular functions, including cell-fate control, brain development and microtubule dynamics. Our data demonstrate an essential role of a miRNA family in brain development, motile ciliogenesis, and spermatogenesis."xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1407777111"xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/author | "Bao J."xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/author | "Kim M."xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/author | "Tang C."xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/author | "Yan W."xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/author | "Yuan S."xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/author | "Zheng H."xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/author | "Mastick G.S."xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/pages | "E2851-7"xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/title | "Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis."xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/24982181 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24982181 |
| http://purl.uniprot.org/citations/24982181 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24982181 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGA8-mappedCitation-24982181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24982181 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGH2-mappedCitation-24982181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24982181 |
| http://purl.uniprot.org/uniprot/#_A0A087WPS6-mappedCitation-24982181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24982181 |
| http://purl.uniprot.org/uniprot/#_A0A087WQQ9-mappedCitation-24982181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24982181 |
| http://purl.uniprot.org/uniprot/#_A0A087WPI9-mappedCitation-24982181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24982181 |
| http://purl.uniprot.org/uniprot/#_A0A087WSM9-mappedCitation-24982181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24982181 |